Copper-Catalyzed Intermolecular C-H Amination of (Hetero)arenes via Transient Unsymmetrical lambda3-Iodanes

Sokolovs, I.; Lubriks, D.; Suna, E. J. Am. Chem. Soc. 2014136, 6920–6928.

DOI: 10.1021/ja502174d

Abstract

A one-pot two-step method for intermolecular C–H amination of electron-rich heteroarenes and arenes has been developed. The approach is based on a room-temperature copper-catalyzed regioselective reaction of the in situ formed unsymmetrical (hetero)aryl-λ3-iodanes with a wide range of primary and secondary aliphatic amines and anilines.