Prof. Dr. Edgars Sūna

 

Curriculum Vitae

Pers. dati

Dzimis: 1970. gada 7. jūnijā

Izglītība

Dr. chem., Latvijas Universitāte, 1999
Disertācijas tēma: “Hirālu 1,2,3,4-tetrahidroizohinolīnu sintēze un izmanošana enantioselektīvajā protonēšanā”
Darba vadītāji:  Prof. E. Vedejs, Dr. P. Trapencieris
 
Mg. chem., Latvijas Universitāte, 1995

Darba pieredze

Latvijas Organiskās sintēzes institūts
Vadošais pētnieks, kopš 2006
Laboratorijas vadītājs, kopš 2003
Pētnieks, 1999-2006
Asistents, 1997-1999
Laborants, 1990-1995
 
Viskonsinas Universitāte Madisonā, ASV
Asistents, 1996 (10 mēneši), 1998 (2 mēneši);
(vadītājs Prof. E. Vedejs)
 
Rīgas Tehniskā Universitāte
Lektors, 2002-2006
Docents, 2006-2013
 
Latvijas Universitāte
Asociētais Profesors, 2008-2013
Profesors, kopš 2013

Apbalvojumi

LZA akadēmiķis, 2014
Gustava Vanaga balva, Latvijas Zinātņu Akadēmija, 2014
Paula Valdena medaļa, Rīgas Tehniskā universitāte, 2013
Latvijas Zinātņu Akadēmijas un a/s Grindeks Jauno zinātnieku balva “Sudraba pūce”, 1998

Vieslekcijas

  1. 7th Asian Chemical Congress, Hiroshima, Japan (May 16-20, 1997)
  2. Balticum Organicum Syntheticum 2010, Riga, Latvia (June 27-30, 2010)
  3. 8th Paul Walden Symposium, Riga, Latvia (May 13-14, 2013)
  4. Heterocycles in Bio-organic Chemistry 2013,  Riga, Latvia (May 27-30, 2013)
  5. 251st American Chemical Society National Meeting, San-Diego, USA (March 13-17, 2016)
  6. Leibniz Institute for Catalysis, Rostock, Germany (May 13, 2016)

 Publikācijas

27. Kinens, A.; Sejejs, M.; Kamlet, A. S.; Piotrowski, D. W.; Vedejs, E.; Suna, E. “Development of a Chiral DMAP Catalyst for the Dynamic Kinetic Resolution of Azole Hemiaminals” J. Org. Chem. 2017, 82, 869-886. DOI: 10.1021/acs.joc.6b02955

26. Priede, M.; Priede, E.; Saame, J.; Leito, I.; Suna, E. “Synthesis of Chiral Phosphazene Bases” Chem. Heterocycl. Comp. 2016, 52, 54-545. DOI: 10.1007/s10593-016-1927-2

25. Sokolovs, I.; Suna, E. “Para-Selective Cu–catalyzed C–H Aryloxylation of Electron-rich Arenes and Heteroarenes” J. Org. Chem. 2016, 81, 371–379. DOI: 10.1021/acs.joc.5b02728

24. Berzina, B.; Sokolovs, I.; Suna, E. “Copper-Catalyzed para–Selective C–H Amination of Electron-Rich Arenes” ACS Catalysis 2015, 5, 7008–7014.DOI: 10.1021/acscatal.5b01992

23. Mutule, I.; Kalnins, T.; Vedejs, E.; Suna, E. “Diazonamide Synthetic Studies. Reactivity of N-Unsubstituted Benzofuro[2,3-b]indolines” Chem. Heterocycl. Comp. 2015, 51, 613-620. PDF

22. Mutule, I.; Joo, B.; Medne, Z.; Kalnins, T.; Vedejs, E.; Suna, E. “Stereoselective Synthesis of the Diazonamide A Macrocyclic Core” J. Org. Chem. 2015, 80, 3058-3066. DOI: 10.1021/jo502941

21. Kinens, A.; Kalnins, T.; Suna, E. “Synthesis of 9-Phenylacridines via Ortho-Lithiation–Cyclization Sequence” Chem. Heterocycl. Comp. 2015, 5, 1501-1505. DOI: 10.1007/s10593-014-1616-y

20. Sokolovs, I.; Lubriks, D.; Suna, E. “Copper-Catalyzed Intermolecular C-H Amination of (Hetero)arenes via Transient Unsymmetrical lambda3-Iodanes”  J. Am. Chem. Soc. 2014136, 6920–6928.  DOI: 10.1021/ja502174d

19. Priede, M.; Kazak, M.; Kalnins, T.; Shubin, K.; Suna, E.  “Diastereoselective Hydroxymethylation of Cyclic Ntert-Butanesulfinylketimines Using Methoxymethanol  as Formaldehyde Source” J. Org. Chem. 201479, 3715–3724. DOI: 10.1021/jo500506u

18. Krasikovs, A; Ozola, V.; Dax, S. L.; Suna, E. “Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles” Synthesis 201345, 683-693.  DOI: 10.1055/s-0032-1316849

17. Suna E.; Shubin K. C–C Cross Coupling via C–H Activation: Intramolecular Reaction of Aryl–H and Hetaryl–H Species. In Metal-Catalyzed Heck-Type Reactions and C-H Couplings, Vol. 3, Science of Synthesis Reference Library; Larhed, M.; Odell, L. R, Eds.; Thieme: Stuttgart, New York, 2012, 928 ppISBN (Americas): 9783131642417

16. Lubriks, D.; Sokolovs, I.; Suna, E. “Indirect C–H Azidation of Heterocycles via Copper-Catalyzed Regioselective Fragmentation of Unsymmetrical λ3-Iodanes” J. Am. Chem. Soc. 2012134, 15436-15442. DOI: 10.1021/ja305574k

15. Suna, E. “Transition-Metal-Catalyzed Acetoxylation of Heterocycles: All that Glitters is not Palladium” Chem. Heterocycl. Comp. 201248, 44-48. DOI: 10.1007/s10593-012-0967-5.  Full Text

14. Lubriks, D.; Sokolovs, I.; Suna, E. “Iodonium Salts Are Key Intermediates in Pd-Catalyzed Acetoxylation of Pyrroles” Org. Lett. 201113, 4324-4327. DOI: 10.1021/ol201665c

13. Martjuga, M.; Belyakov, S.; Liepinsh, E.; Suna, E. “Asymmetric Synthesis of 1,3-Diamines. II: Diastereoselective Reduction of Atropisomeric Ntert-Butanesulfinylketimines” J. Org. Chem. 201176, 2635-2647. DOI: 10.1021/jo1025767

12. Martjuga, M.; Shabashov, D.; Belyakov, S.; Liepinsh, E.; Suna, E. “Asymmetric Synthesis of 1,3-Diamines by Diastereoselective Reduction of Enantiopure Ntert-Butanesulfinylketimines: Unusual Directing Effects of the ortho-Substituent” J. Org. Chem. 2010, 75, 2375-2368. DOI: 10.1021/jo100173f

11. Mutule, I.; Suna, E.; Olofsson, K.; Pelcman, B. “Catalytic Direct Acetoxylation of Indoles” J. Org. Chem. 200974, 7195-7198. DOI: 10.1021/jo901321b

10. Katkevičs M.; Kontijevskis A.; Mutule I.; Sūna E. “Microwave Promoted Automated Synthesis of Coumarin Library” Chem. Heterocycl. Comp. 2007, 151-159. DOI: 10.1007/s10593-007-0025-x

9. Suna E.; Mutule I. Microwave-assisted Heterocyclic Chemistry. In Microwave Methods in Organic Synthesis; Larhed, M.; Olofsson, K., Eds.; Topics in Current Chemistry; Springer: Berlin, 2006; Vol. 266, pp 49-101. DOI: 10.1007/128_058

8. Mutule, I.; Suna E. “Arylzinc species by microwave assisted Grignard formation – transmetallation sequence: application in the Negishi coupling” Tetrahedron 200561, 11168-11176. DOI: 10.1016/j.tet.2005.09.022

7. Mutule, I.; Suna E. “A convenient microwave assisted arylzinc generation-Negishi coupling protocol” Tetrahedron Lett. 200445, 3909-3912. DOI: 10.1016/j.tetlet.2004.03.118

6. Pottorf, R. S.; Chadha, N. K.; Katkevics, M., Ozola, V., Suna, E.; Ghane, H.; Regberg, T.; Player M. R. “Parallel synthesis of benzoxazoles via microwave-assisted dielectric heating” Tetrahedron Lett. 200344, 175-178. DOI: 10.1016/S0040-4039(02)02495-4

5. Suna, E. “Resolution of 1-Aryl-1,2,3,4-Tetrahydroisoquinolines via Crystallization of O-Acetylmandelic Amides” Synthesis 2003, 251-254. DOI: 10.1055/s-2003-36832

4. Vedejs, E.; Kruger, A. W.; Lee, N.; Sakata, S. T.; Stec, M.; Suna, E. “Enantioselective Enolate Protonation with Chiral Anilines: Scope, Structural Requirements, and Mechanistic Implications” J. Am. Chem. Soc. 2000122, 4602-4607. DOI: 10.1021/ja994437m

3. Suna, E.; Trapencieris, P. “Synthesis of Racemic 1,2,3,4-Tetrahydroisoquinolines and Their Resolution” Chem. Heterocycl. Comp. 2000, 348-361. DOI: 10.1007/BF02256866

2. Vedejs, E.; Kruger, A.W.; Suna, E. “Enantioselective Enolate Protonation: Matching Chiral Aniline and Substrate Acidity” J. Org. Chem. 199964, 7863-7870. DOI: 10.1021/jo990897m

1. Vedejs, E.; Trapencieris, P.; Suna, E. “Substituted Isoquinolines by Noyori Transfer Hydrogenation; Enantioselective Synthesis of Chiral Diamines Containing an Aniline Subunit” J. Org. Chem. 199964, 6724-6729. DOI: 10.1021/jo990594s

Patenti

25. Berzina, B.; Mutule, I.; Suna, E. Hydridopalladium(II) Halides as Preformed Catalysts for Suzuki-Miyaura Cross-Coupling Reactions. WO2015/063543 A1, 7 May, 2015

24. Dax, S. L.; Mencel, J. J.; Ozola, V.; Shubin, K.; Martjuga, M.; Suna, E. Novel Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/151462 A1, 25 September, 2014

23. Mannion, J. C.; Dax, S. L.; Golder, F. J.; Macintyre, D. E.; McLeod, J.; Ozola, V.; Suna, E.; Shubin, K.; Mencel, J. J.; Peng, S. X. Novel Orally Bioavailable Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/078575 A2, 22 May, 2014

22. Dax, S.L.; Ozola, V.; Krasikovs, A.; Suna, E. Novel Methods for Preparation of (+)-1-ethyl-4-[2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone and Salts Thereof. US2013/109854  A1, 5 May, 2013

21. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. Imidazo(4,5-b)pyridine-6-carboxamides as anti-inflammatory agents. WO2012/076674 A1, 14 June, 2012

20. Priepke, H.; Kuelzer, R.; Mack, J.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. 2-Aminobenz imidazole derivatives useful in the treatment of inflammation WO2012/076672 A1, 14 June, 2012

19. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna, E. 2-(Arylamino)-3H-imidazo-[4,5-b]-pyridine-6-carboxamide derivatives and their use as MPGES-1 inhibitors. WO2012/022792 A1, 23 February, 2012

18. Nilsson, P.; Pelcman, B.; Katkevics, M.; Suna, E.; Popovs, I. Bis aromatic compounds for use as LTC4 synthase inhibitors. WO 2010/103283 A1, 16 September, 2010

17. Pfau, R.; Arndt, K.; Doods, H.; Klinder, K.; Kuelzer, R.; Lubriks, D.; Mack, J.; Pelcman, B.; Priepke, H.; Rönn, R.; Stenkamp, D.; Suna, E. 3H-Imidazo-[4,5-c]-pyridine-6-carboxamides as anti-inflammatory agents. WO2010/100249 A1, 10 September, 2010

16. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Andrianov, V. Disulfonamides useful in the treatment of inflammation. WO 2008/129276 A1, 30 October, 2008

15. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Krasikovs, A. Disulfonamides useful in the treatment of inflammation. WO 2008/129288 A2, 30 October, 2008

14. Pelcman, B.; Olofsson, K.; Kalvins, I.; Suna, E.; Ozola, V.; Schaal, W. Benzoxazoles useful in the treatment of inflammation. WO 2008/071944, 19 June, 2008

13. Pelcman B.; Olofsson K.; Katkevics M.; Ozola V.; Suna E.; Kalvins I.; Arsenjans P. Indoles useful in the treatment of inflammation. WO 2008/009924 A2, 24 January, 2008

12. Pelcman, B; Olofsson, K.; Habarova, O.; Kalvins, I.; Suna, E.; Trapencieris, P.; Andrianov, V. Naphthalene-disulfonamides useful for the treatment of inflammation. WO 2007/042817 A1, 19 April 2007

11. Pelcman, B; Olofsson, K.; Schaal, W.; Kalvins, I.; Katkevics, M.; Ozola, V.; Suna E. Benzoxazoles useful in the treatment of inflammation. WO 2007/042816 A1, 19 April 2007

10. Pelcman, B; Olofsson, K.; Arsenjans, P.; Ozola, V.; Suna E.; Kalvins, I. Thienopyrroles useful in the treatment of inflammation. WO 2006/077412 A1, 27 July 2006

9. Pelcman, B; Olofsson, K.; Arsenjans, P.; Kalvins, I.; Suna E.;. Katkevics, M.; Madre, M.; Ozola, V. Pyrrolopyridines useful in the treatment of inflammation. WO 2006/077401 A1, 27 July 2006

8. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077367 A1, 27 July 2006

7. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077366 A1, 27 July 2006

6. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077365 A1, 27 July 2006

5. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P. Indoles useful in the treatment of inflammation. WO 2006/077364 A1, 27 July 2006

4. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123675 A1, 29 Dec 2005

3. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123674 A1, 29 Dec 2005

2. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/123673 A1, 29 Dec 2005

1. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/005415 A1, 20 Jan 2005

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