Prof. Dr. Edgars Suna

 

Curriculum Vitae

Born

June 7th, 1970

Education

PhD in chemistry, University of Latvia, 1999
Thesis: “Chiral 1,2,3,4-Tetrahydroisoquinolines: Synthesis and Use in Enantioselective Protonation”
Supervisors: Prof. E. Vedejs, Dr. P. Trapencieris
 
Diploma, Chemistry, University of Latvia, 1993

Experience

Latvian Institute of Organic Synthesis
Principal Scientist, 2006-present
Head of Laboratory, 2003-present
Researcher, 1999-2006
Research Assistant, 1997-1999
Laboratory Assistant, 1990-1995
 
University of Wisconsin-Madison, USA
Research Assistant, 1996 (10 months), 1998 (2 months);
(advisor Prof. E. Vedejs)
 
Riga Technical University
Lecturer, 2002-2006
Docent, 2006-2013
 
University of Latvia
Associate Professor, 2008-2013
Professor of Chemistry, 2013-present

Honors and Awards

Full Member Latvian Academy of Sciences, 2014
Gustavs Vanags Prize, Latvian Academy of Sciences, 2014
Paul Walden Medal, Riga Technical University, 2013
Latvian Academy of Sciences and Grindeks, Ltd Award for Young Scientist, year 1998

Invited Lectures

  1. 7th Asian Chemical Congress, Hiroshima, Japan (May 16-20, 1997)
  2. Balticum Organicum Syntheticum 2010, Riga, Latvia (June 27-30, 2010)
  3. 8th Paul Walden Symposium, Riga, Latvia (May 13-14, 2013)
  4. Heterocycles in Bio-organic Chemistry 2013,  Riga, Latvia (May 27-30, 2013)
  5. 251st American Chemical Society National Meeting, San-Diego, USA (March 13-17, 2016)
  6. Leibniz Institute for Catalysis, Rostock, Germany (May 13, 2016)

 

Publications

27. Kinens, A.; Sejejs, M.; Kamlet, A. S.; Piotrowski, D. W.; Vedejs, E.; Suna, E. “Development of a Chiral DMAP Catalyst for the Dynamic Kinetic Resolution of Azole Hemiaminals” J. Org. Chem. 2017, 82, 869-886. DOI: 10.1021/acs.joc.6b02955

26. Priede, M.; Priede, E.; Saame, J.; Leito, I.; Suna, E. “Synthesis of Chiral Phosphazene Bases” Chem. Heterocycl. Comp. 2016, 52, 54-545. DOI: 10.1007/s10593-016-1927-2

25. Sokolovs, I.; Suna, E. “Para-Selective Cu–catalyzed C–H Aryloxylation of Electron-rich Arenes and Heteroarenes” J. Org. Chem. 2016, 81, 371–379. DOI: 10.1021/acs.joc.5b02728

24. Berzina, B.; Sokolovs, I.; Suna, E. “Copper-Catalyzed para–Selective C–H Amination of Electron-Rich Arenes” ACS Catalysis 2015, 5, 7008–7014.DOI: 10.1021/acscatal.5b01992

23. Mutule, I.; Kalnins, T.; Vedejs, E.; Suna, E. “Diazonamide Synthetic Studies. Reactivity of N-Unsubstituted Benzofuro[2,3-b]indolines” Chem. Heterocycl. Comp. 2015, 51, 613-620. PDF

22. Mutule, I.; Joo, B.; Medne, Z.; Kalnins, T.; Vedejs, E.; Suna, E. “Stereoselective Synthesis of the Diazonamide A Macrocyclic Core” J. Org. Chem. 2015, 80, 3058-3066. DOI: 10.1021/jo502941

21. Kinens, A.; Kalnins, T.; Suna, E. “Synthesis of 9-Phenylacridines via Ortho-Lithiation–Cyclization Sequence” Chem. Heterocycl. Comp. 2015, 5, 1501-1505. DOI: 10.1007/s10593-014-1616-y

20. Sokolovs, I.; Lubriks, D.; Suna, E. “Copper-Catalyzed Intermolecular C-H Amination of (Hetero)arenes via Transient Unsymmetrical lambda3-Iodanes”  J. Am. Chem. Soc. 2014136, 6920–6928.  DOI: 10.1021/ja502174d

19. Priede, M.; Kazak, M.; Kalnins, T.; Shubin, K.; Suna, E.  “Diastereoselective Hydroxymethylation of Cyclic Ntert-Butanesulfinylketimines Using Methoxymethanol  as Formaldehyde Source” J. Org. Chem. 201479, 3715–3724. DOI: 10.1021/jo500506u

18. Krasikovs, A; Ozola, V.; Dax, S. L.; Suna, E. “Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles” Synthesis 201345, 683-693.  DOI: 10.1055/s-0032-1316849

17. Suna E.; Shubin K. C–C Cross Coupling via C–H Activation: Intramolecular Reaction of Aryl–H and Hetaryl–H Species. In Metal-Catalyzed Heck-Type Reactions and C-H Couplings, Vol. 3, Science of Synthesis Reference Library; Larhed, M.; Odell, L. R, Eds.; Thieme: Stuttgart, New York, 2012, 928 ppISBN (Americas): 9783131642417

16. Lubriks, D.; Sokolovs, I.; Suna, E. “Indirect C–H Azidation of Heterocycles via Copper-Catalyzed Regioselective Fragmentation of Unsymmetrical λ3-Iodanes” J. Am. Chem. Soc. 2012134, 15436-15442. DOI: 10.1021/ja305574k

15. Suna, E. “Transition-Metal-Catalyzed Acetoxylation of Heterocycles: All that Glitters is not Palladium” Chem. Heterocycl. Comp. 201248, 44-48. DOI: 10.1007/s10593-012-0967-5.  Full Text

14. Lubriks, D.; Sokolovs, I.; Suna, E. “Iodonium Salts Are Key Intermediates in Pd-Catalyzed Acetoxylation of Pyrroles” Org. Lett. 201113, 4324-4327. DOI: 10.1021/ol201665c

13. Martjuga, M.; Belyakov, S.; Liepinsh, E.; Suna, E. “Asymmetric Synthesis of 1,3-Diamines. II: Diastereoselective Reduction of Atropisomeric Ntert-Butanesulfinylketimines” J. Org. Chem. 201176, 2635-2647. DOI: 10.1021/jo1025767

12. Martjuga, M.; Shabashov, D.; Belyakov, S.; Liepinsh, E.; Suna, E. “Asymmetric Synthesis of 1,3-Diamines by Diastereoselective Reduction of Enantiopure Ntert-Butanesulfinylketimines: Unusual Directing Effects of the ortho-Substituent” J. Org. Chem. 2010, 75, 2375-2368. DOI: 10.1021/jo100173f

11. Mutule, I.; Suna, E.; Olofsson, K.; Pelcman, B. “Catalytic Direct Acetoxylation of Indoles” J. Org. Chem. 200974, 7195-7198. DOI: 10.1021/jo901321b

10. Katkevičs M.; Kontijevskis A.; Mutule I.; Sūna E. “Microwave Promoted Automated Synthesis of Coumarin Library” Chem. Heterocycl. Comp. 2007, 151-159. DOI: 10.1007/s10593-007-0025-x

9. Suna E.; Mutule I. Microwave-assisted Heterocyclic Chemistry. In Microwave Methods in Organic Synthesis; Larhed, M.; Olofsson, K., Eds.; Topics in Current Chemistry; Springer: Berlin, 2006; Vol. 266, pp 49-101. DOI: 10.1007/128_058

8. Mutule, I.; Suna E. “Arylzinc species by microwave assisted Grignard formation – transmetallation sequence: application in the Negishi coupling” Tetrahedron 200561, 11168-11176. DOI: 10.1016/j.tet.2005.09.022

7. Mutule, I.; Suna E. “A convenient microwave assisted arylzinc generation-Negishi coupling protocol” Tetrahedron Lett. 200445, 3909-3912. DOI: 10.1016/j.tetlet.2004.03.118

6. Pottorf, R. S.; Chadha, N. K.; Katkevics, M., Ozola, V., Suna, E.; Ghane, H.; Regberg, T.; Player M. R. “Parallel synthesis of benzoxazoles via microwave-assisted dielectric heating” Tetrahedron Lett. 200344, 175-178. DOI: 10.1016/S0040-4039(02)02495-4

5. Suna, E. “Resolution of 1-Aryl-1,2,3,4-Tetrahydroisoquinolines via Crystallization of O-Acetylmandelic Amides” Synthesis 2003, 251-254. DOI: 10.1055/s-2003-36832

4. Vedejs, E.; Kruger, A. W.; Lee, N.; Sakata, S. T.; Stec, M.; Suna, E. “Enantioselective Enolate Protonation with Chiral Anilines: Scope, Structural Requirements, and Mechanistic Implications” J. Am. Chem. Soc. 2000122, 4602-4607. DOI: 10.1021/ja994437m

3. Suna, E.; Trapencieris, P. “Synthesis of Racemic 1,2,3,4-Tetrahydroisoquinolines and Their Resolution” Chem. Heterocycl. Comp. 2000, 348-361. DOI: 10.1007/BF02256866

2. Vedejs, E.; Kruger, A.W.; Suna, E. “Enantioselective Enolate Protonation: Matching Chiral Aniline and Substrate Acidity” J. Org. Chem. 199964, 7863-7870. DOI: 10.1021/jo990897m

1. Vedejs, E.; Trapencieris, P.; Suna, E. “Substituted Isoquinolines by Noyori Transfer Hydrogenation; Enantioselective Synthesis of Chiral Diamines Containing an Aniline Subunit” J. Org. Chem. 199964, 6724-6729. DOI: 10.1021/jo990594s

Patents

25. Berzina, B.; Mutule, I.; Suna, E. Hydridopalladium(II) Halides as Preformed Catalysts for Suzuki-Miyaura Cross-Coupling Reactions. WO2015/063543 A1, 7 May, 2015

24. Dax, S. L.; Mencel, J. J.; Ozola, V.; Shubin, K.; Martjuga, M.; Suna, E. Novel Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/151462 A1, 25 September, 2014

23. Mannion, J. C.; Dax, S. L.; Golder, F. J.; Macintyre, D. E.; McLeod, J.; Ozola, V.; Suna, E.; Shubin, K.; Mencel, J. J.; Peng, S. X. Novel Orally Bioavailable Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/078575 A2, 22 May, 2014

22. Dax, S.L.; Ozola, V.; Krasikovs, A.; Suna, E. Novel Methods for Preparation of (+)-1-ethyl-4-[2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone and Salts Thereof. US2013/109854  A1, 5 May, 2013

21. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. Imidazo(4,5-b)pyridine-6-carboxamides as anti-inflammatory agents. WO2012/076674 A1, 14 June, 2012

20. Priepke, H.; Kuelzer, R.; Mack, J.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. 2-Aminobenz imidazole derivatives useful in the treatment of inflammation WO2012/076672 A1, 14 June, 2012

19. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna, E. 2-(Arylamino)-3H-imidazo-[4,5-b]-pyridine-6-carboxamide derivatives and their use as MPGES-1 inhibitors. WO2012/022792 A1, 23 February, 2012

18. Nilsson, P.; Pelcman, B.; Katkevics, M.; Suna, E.; Popovs, I. Bis aromatic compounds for use as LTC4 synthase inhibitors. WO 2010/103283 A1, 16 September, 2010

17. Pfau, R.; Arndt, K.; Doods, H.; Klinder, K.; Kuelzer, R.; Lubriks, D.; Mack, J.; Pelcman, B.; Priepke, H.; Rönn, R.; Stenkamp, D.; Suna, E. 3H-Imidazo-[4,5-c]-pyridine-6-carboxamides as anti-inflammatory agents. WO2010/100249 A1, 10 September, 2010

16. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Andrianov, V. Disulfonamides useful in the treatment of inflammation. WO 2008/129276 A1, 30 October, 2008

15. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Krasikovs, A. Disulfonamides useful in the treatment of inflammation. WO 2008/129288 A2, 30 October, 2008

14. Pelcman, B.; Olofsson, K.; Kalvins, I.; Suna, E.; Ozola, V.; Schaal, W. Benzoxazoles useful in the treatment of inflammation. WO 2008/071944, 19 June, 2008

13. Pelcman B.; Olofsson K.; Katkevics M.; Ozola V.; Suna E.; Kalvins I.; Arsenjans P. Indoles useful in the treatment of inflammation. WO 2008/009924 A2, 24 January, 2008

12. Pelcman, B; Olofsson, K.; Habarova, O.; Kalvins, I.; Suna, E.; Trapencieris, P.; Andrianov, V. Naphthalene-disulfonamides useful for the treatment of inflammation. WO 2007/042817 A1, 19 April 2007

11. Pelcman, B; Olofsson, K.; Schaal, W.; Kalvins, I.; Katkevics, M.; Ozola, V.; Suna E. Benzoxazoles useful in the treatment of inflammation. WO 2007/042816 A1, 19 April 2007

10. Pelcman, B; Olofsson, K.; Arsenjans, P.; Ozola, V.; Suna E.; Kalvins, I. Thienopyrroles useful in the treatment of inflammation. WO 2006/077412 A1, 27 July 2006

9. Pelcman, B; Olofsson, K.; Arsenjans, P.; Kalvins, I.; Suna E.;. Katkevics, M.; Madre, M.; Ozola, V. Pyrrolopyridines useful in the treatment of inflammation. WO 2006/077401 A1, 27 July 2006

8. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077367 A1, 27 July 2006

7. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077366 A1, 27 July 2006

6. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077365 A1, 27 July 2006

5. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P. Indoles useful in the treatment of inflammation. WO 2006/077364 A1, 27 July 2006

4. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123675 A1, 29 Dec 2005

3. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123674 A1, 29 Dec 2005

2. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/123673 A1, 29 Dec 2005

1. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/005415 A1, 20 Jan 2005

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