Prof. Dr. Edgars Suna

Prof. Dr. Edgars Suna

Head of Laboratory

Curriculum Vitae

Born

June 7th, 1970

Education

PhD in chemistry, University of Latvia, 1999
Thesis: “Chiral 1,2,3,4-Tetrahydroisoquinolines: Synthesis and Use in Enantioselective Protonation”
Supervisors: Prof. E. Vedejs, Dr. P. Trapencieris

Experience

Latvian Institute of Organic Synthesis
Principal Scientist, 2006-present
Head of Laboratory, 2003-present
Researcher, 1999-2006
Research Assistant, 1997-1999
Laboratory Assistant, 1990-1995

University of Wisconsin-Madison, USA
Research Assistant, 1996 (10 months), 1998 (2 months);
(advisor Prof. E. Vedejs)

Riga Technical University
Lecturer, 2002-2006
Docent, 2006-2018
Visiting Professor, 2018-present

University of Latvia
Associate Professor, 2008-2013
Professor of Chemistry, 2013-present

Honors and Awards

Walter Zapp prize, Latvian Academy of Sciences, Latvian Patent Office and Minox GmbH (Germany), 2017
Full Member Latvian Academy of Sciences, 2014
Gustavs Vanags Prize, Latvian Academy of Sciences, 2014
Paul Walden Medal, Riga Technical University, 2013
Latvian Academy of Sciences and Grindeks, Ltd Award for Young Scientist, year 1998

Invited Lectures

  1. Markovnikov Congress on Organic Chemistry, Moscow-Kazan, Russia, (June 21-28, 2019)
  2. Leibniz Institute for Catalysis, Rostock, Germany (May 13, 2016)
  3. 251st American Chemical Society National Meeting, San-Diego, USA (March 13-17, 2016)
  4. Heterocycles in Bio-organic Chemistry 2013,  Riga, Latvia (May 27-30, 2013)
  5. 8th Paul Walden Symposium, Riga, Latvia (May 13-14, 2013)
  6. Balticum Organicum Syntheticum 2010, Riga, Latvia (June 27-30, 2010)
  7. 7th Asian Chemical Congress, Hiroshima, Japan (May 16-20, 1997)

Publications

  1. Grandane, A.; Longowitz, L.; Roolf, C.; Spannenberg, A.; Escobar, H. M.; Junghanss, C.; Suna, E.; Werner, T. “Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones” J. Org. Chem. 2019, 84, 1320–1329. DOI: 10.1021/acs.joc.8b02789
  2. Leduskrasts, K.; Suna, E. “Aggregation induced emission by pyridinium–pyridinium interactions” RSC Advances 2019, 9, 460-465. DOI: 10.1039/C8RA08771G
  3. Dumont, E.; Vergalli, J.; Pajovic, J.; Bhamidimarri, S. P.; Morante, K.; Wang, J.; Lubriks, D.; Suna, E.; Stavenger, R. A.; Winterhalter, M.; Refregiers, M.; Pages, J. M. “Mechanistic aspects of maltotriose-conjugate
    translocation to the Gram-negative bacteria cytoplasm” Life Science Alliance 2019, 2, e201800242. DOI: 10.26508/lsa.201800242
  4. Zogota, R.; Kinena, L.; Withers-Martinez, C.; Blackman, M. J.; Bobrovs, R.; Pantelejevs, T.; Kanepe-Lapsa, I.; Ozola, V.; Jaudzems, K.; Suna, E.; Jirgensons, A. “Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D” Eur. J. Med. Chem. 2019, 163, 344-352. DOI: 10.1016/j.ejmech.2018.11.068
  5. Kinens, A.; Balkaitis, S.; Suna, E. “Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts” J. Org. Chem. 2018, 83, 12449–12459. DOI: 10.1021/acs.joc.8b01687
  6. Kinena, L.; Leitis, G.; Kanepe-Lapsa, I.; Bobrovs, R.; Jaudzems. K.; Ozola, V.; Suna, E.; Jirgensons, A. “Azole‐based non‐peptidomimetic plasmepsin inhibitors” Arch. Pharm. Chem. Life Sci. 2018, 351, 1800151. DOI: 10.1002/ardp.201800151
  7. Koleda, O.; Broese, T.; Noetzel, J.; Roemelt, M.; Suna, E.; Francke, R. “Synthesis of Benzoxazoles Using Electrochemically Generated Hypervalent Iodine” J. Org. Chem. 201782, 11669–11681. DOI: 10.1021/acs.joc.7b01686
  8. Kazak, M.; Priede, M.; Shubin, K.; Bartrum, H. E.; Poisson, J.-F.; Suna, E. “Stereodivergent Synthesis of Pseudotabersonine Alkaloids” Org. Lett. 201719, 5356–5359. DOI: 10.1021/acs.orglett.7b02635
  9. Kinens, A.; Sejejs, M.; Kamlet, A. S.; Piotrowski, D. W.; Vedejs, E.; Suna, E. “Development of a Chiral DMAP Catalyst for the Dynamic Kinetic Resolution of Azole Hemiaminals” J. Org. Chem. 201782, 869-886.DOI: 10.1021/acs.joc.6b02955
  10. Priede, M.; Priede, E.; Saame, J.; Leito, I.; Suna, E. “Synthesis of Chiral Phosphazene Bases” Chem. Heterocycl. Comp. 201652, 54-545. DOI: 10.1007/s10593-016-1927-2
  11. Sokolovs, I.; Suna, E. “Para-Selective Cu–catalyzed C–H Aryloxylation of Electron-rich Arenes and Heteroarenes” J. Org. Chem. 201681, 371–379. DOI: 10.1021/acs.joc.5b02728
  12. Berzina, B.; Sokolovs, I.; Suna, E. “Copper-Catalyzed para–Selective C–H Amination of Electron-Rich Arenes” ACS Catalysis 20155, 7008–7014.DOI: 10.1021/acscatal.5b01992
  13. Mutule, I.; Kalnins, T.; Vedejs, E.; Suna, E. “Diazonamide Synthetic Studies. Reactivity of N-Unsubstituted Benzofuro[2,3-b]indolines” Chem. Heterocycl. Comp. 201551, 613-620. PDF
  14. Mutule, I.; Joo, B.; Medne, Z.; Kalnins, T.; Vedejs, E.; Suna, E. “Stereoselective Synthesis of the Diazonamide A Macrocyclic Core” J. Org. Chem. 201580, 3058-3066. DOI: 10.1021/jo502941
  15. Kinens, A.; Kalnins, T.; Suna, E. “Synthesis of 9-Phenylacridines via Ortho-Lithiation–Cyclization Sequence” Chem. Heterocycl. Comp. 20155, 1501-1505DOI: 10.1007/s10593-014-1616-y
  16. Sokolovs, I.; Lubriks, D.; Suna, E. “Copper-Catalyzed Intermolecular C-H Amination of (Hetero)arenes via Transient Unsymmetrical lambda3-Iodanes”  J. Am. Chem. Soc. 2014136, 6920–6928.  DOI: 10.1021/ja502174d
  17. Priede, M.; Kazak, M.; Kalnins, T.; Shubin, K.; Suna, E.  “Diastereoselective Hydroxymethylation of Cyclic Ntert-Butanesulfinylketimines Using Methoxymethanol  as Formaldehyde Source” J. Org. Chem. 201479, 3715–3724. DOI: 10.1021/jo500506u
  18. Krasikovs, A; Ozola, V.; Dax, S. L.; Suna, E. “Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles” Synthesis 201345, 683-693.  DOI: 10.1055/s-0032-1316849
  19. Suna E.; Shubin K. C–C Cross Coupling via C–H Activation: Intramolecular Reaction of Aryl–H and Hetaryl–H Species. In Metal-Catalyzed Heck-Type Reactions and C-H Couplings, Vol. 3, Science of Synthesis Reference Library; Larhed, M.; Odell, L. R, Eds.; Thieme: Stuttgart, New York, 2012, 928 ppISBN (Americas): 9783131642417
  20. Lubriks, D.; Sokolovs, I.; Suna, E. “Indirect C–H Azidation of Heterocycles via Copper-Catalyzed Regioselective Fragmentation of Unsymmetrical λ3-Iodanes” J. Am. Chem. Soc. 2012134, 15436-15442. DOI: 10.1021/ja305574k
  21. Suna, E. “Transition-Metal-Catalyzed Acetoxylation of Heterocycles: All that Glitters is not Palladium” Chem. Heterocycl. Comp. 201248, 44-48. DOI: 10.1007/s10593-012-0967-5.  Full Text
  22. Lubriks, D.; Sokolovs, I.; Suna, E. “Iodonium Salts Are Key Intermediates in Pd-Catalyzed Acetoxylation of Pyrroles” Org. Lett. 201113, 4324-4327. DOI: 10.1021/ol201665c
  23. Martjuga, M.; Belyakov, S.; Liepinsh, E.; Suna, E. “Asymmetric Synthesis of 1,3-Diamines. II: Diastereoselective Reduction of Atropisomeric Ntert-Butanesulfinylketimines” J. Org. Chem. 201176, 2635-2647. DOI: 10.1021/jo1025767
  24. Martjuga, M.; Shabashov, D.; Belyakov, S.; Liepinsh, E.; Suna, E. “Asymmetric Synthesis of 1,3-Diamines by Diastereoselective Reduction of Enantiopure Ntert-Butanesulfinylketimines: Unusual Directing Effects of the ortho-Substituent” J. Org. Chem. 2010, 75, 2375-2368. DOI: 10.1021/jo100173f
  25. Mutule, I.; Suna, E.; Olofsson, K.; Pelcman, B. “Catalytic Direct Acetoxylation of Indoles” J. Org. Chem. 200974, 7195-7198. DOI: 10.1021/jo901321b
  26. Katkevičs M.; Kontijevskis A.; Mutule I.; Sūna E. “Microwave Promoted Automated Synthesis of Coumarin Library” Chem. Heterocycl. Comp. 2007, 151-159. DOI: 10.1007/s10593-007-0025-x
  27. Suna E.; Mutule I. Microwave-assisted Heterocyclic Chemistry. In Microwave Methods in Organic Synthesis; Larhed, M.; Olofsson, K., Eds.; Topics in Current Chemistry; Springer: Berlin, 2006; Vol. 266, pp 49-101. DOI: 10.1007/128_058
  28. Mutule, I.; Suna E. “Arylzinc species by microwave assisted Grignard formation – transmetallation sequence: application in the Negishi coupling” Tetrahedron 200561, 11168-11176. DOI: 10.1016/j.tet.2005.09.022
  29. Mutule, I.; Suna E. “A convenient microwave assisted arylzinc generation-Negishi coupling protocol” Tetrahedron Lett. 200445, 3909-3912. DOI: 10.1016/j.tetlet.2004.03.118
  30. Pottorf, R. S.; Chadha, N. K.; Katkevics, M., Ozola, V., Suna, E.; Ghane, H.; Regberg, T.; Player M. R. “Parallel synthesis of benzoxazoles via microwave-assisted dielectric heating” Tetrahedron Lett. 200344, 175-178. DOI: 10.1016/S0040-4039(02)02495-4
  31. Suna, E. “Resolution of 1-Aryl-1,2,3,4-Tetrahydroisoquinolines via Crystallization of O-Acetylmandelic Amides” Synthesis 2003, 251-254. DOI: 10.1055/s-2003-36832
  32. Vedejs, E.; Kruger, A. W.; Lee, N.; Sakata, S. T.; Stec, M.; Suna, E. “Enantioselective Enolate Protonation with Chiral Anilines: Scope, Structural Requirements, and Mechanistic Implications” J. Am. Chem. Soc. 2000122, 4602-4607. DOI: 10.1021/ja994437m
  33. Suna, E.; Trapencieris, P. “Synthesis of Racemic 1,2,3,4-Tetrahydroisoquinolines and Their Resolution” Chem. Heterocycl. Comp. 2000, 348-361. DOI: 10.1007/BF02256866
  34. Vedejs, E.; Kruger, A.W.; Suna, E. “Enantioselective Enolate Protonation: Matching Chiral Aniline and Substrate Acidity” J. Org. Chem. 199964, 7863-7870. DOI: 10.1021/jo990897m
  35. Vedejs, E.; Trapencieris, P.; Suna, E. “Substituted Isoquinolines by Noyori Transfer Hydrogenation; Enantioselective Synthesis of Chiral Diamines Containing an Aniline Subunit” J. Org. Chem. 199964, 6724-6729. DOI: 10.1021/jo990594s

Patents

  1. Pelcman, B.; Suna, E.; Stafford, W.; Priede, M. Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer. WO 2018/146469 A1, 16 Aug, 2018
  2. Kinena, L.; Ozola, V.; Suna, E.; Leitis, G.; Jirgensons, A.; Jaudzems, K.; Kanepe-Lapsa, I.; Domracheva, I. 2. Substituted aminoalkylazoles as malarial aspartic protease inhibitors. WO 2017/069601 A1, 27 Apr, 2017
  3. Dax, S. L.; Mencel, J. J.; Ozola, V.; Suna, E.; Shubin, K. Preparation of pyrimido[5,4-d]pyrimidine derivatives as novel breathing control modulating compounds for preventing and/or treating respiratory diseases WO 2017/003822 A1, 5 Jan, 2017
  4. Berzina, B.; Mutule, I.; Suna, E. Hydridopalladium(II) Halides as Preformed Catalysts for Suzuki-Miyaura Cross-Coupling Reactions. WO 2015/063543 A1, 7 May, 2015
  5. Dax, S. L.; Mencel, J. J.; Ozola, V.; Shubin, K.; Martjuga, M.; Suna, E. Novel Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/151462 A1, 25 September, 2014
  6. Mannion, J. C.; Dax, S. L.; Golder, F. J.; Macintyre, D. E.; McLeod, J.; Ozola, V.; Suna, E.; Shubin, K.; Mencel, J. J.; Peng, S. X. Novel Orally Bioavailable Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/078575 A2, 22 May, 2014
  7. Dax, S.L.; Ozola, V.; Krasikovs, A.; Suna, E. Novel Methods for Preparation of (+)-1-ethyl-4-[2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone and Salts Thereof. US 2013/109854  A1, 5 May, 2013
  8. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. Imidazo(4,5-b)pyridine-6-carboxamides as anti-inflammatory agents. WO 2012/076674 A1, 14 June, 2012
  9. Priepke, H.; Kuelzer, R.; Mack, J.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. 2-Aminobenz imidazole derivatives useful in the treatment of inflammation WO 2012/076672 A1, 14 June, 2012
  10. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna, E. 2-(Arylamino)-3H-imidazo-[4,5-b]-pyridine-6-carboxamide derivatives and their use as MPGES-1 inhibitors. WO 2012/022792 A1, 23 February, 2012
  11. Nilsson, P.; Pelcman, B.; Katkevics, M.; Suna, E.; Popovs, I. Bis aromatic compounds for use as LTC4 synthase inhibitors. WO 2010/103283 A1, 16 September, 2010
  12. Pfau, R.; Arndt, K.; Doods, H.; Klinder, K.; Kuelzer, R.; Lubriks, D.; Mack, J.; Pelcman, B.; Priepke, H.; Rönn, R.; Stenkamp, D.; Suna, E. 3H-Imidazo-[4,5-c]-pyridine-6-carboxamides as anti-inflammatory agents. WO 2010/100249 A1, 10 September, 2010
  13. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Andrianov, V. Disulfonamides useful in the treatment of inflammation. WO 2008/129276 A1, 30 October, 2008
  14. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Krasikovs, A. Disulfonamides useful in the treatment of inflammation. WO 2008/129288 A2, 30 October, 2008
  15. Pelcman, B.; Olofsson, K.; Kalvins, I.; Suna, E.; Ozola, V.; Schaal, W. Benzoxazoles useful in the treatment of inflammation. WO 2008/071944, 19 June, 2008
  16. Pelcman B.; Olofsson K.; Katkevics M.; Ozola V.; Suna E.; Kalvins I.; Arsenjans P. Indoles useful in the treatment of inflammation. WO 2008/009924 A2, 24 January, 2008
  17. Pelcman, B; Olofsson, K.; Habarova, O.; Kalvins, I.; Suna, E.; Trapencieris, P.; Andrianov, V. Naphthalene-disulfonamides useful for the treatment of inflammation. WO 2007/042817 A1, 19 April 2007
  18. Pelcman, B; Olofsson, K.; Schaal, W.; Kalvins, I.; Katkevics, M.; Ozola, V.; Suna E. Benzoxazoles useful in the treatment of inflammation. WO 2007/042816 A1, 19 April 2007
  19. Pelcman, B; Olofsson, K.; Arsenjans, P.; Ozola, V.; Suna E.; Kalvins, I. Thienopyrroles useful in the treatment of inflammation. WO 2006/077412 A1, 27 July 2006
  20. Pelcman, B; Olofsson, K.; Arsenjans, P.; Kalvins, I.; Suna E.;. Katkevics, M.; Madre, M.; Ozola, V. Pyrrolopyridines useful in the treatment of inflammation. WO 2006/077401 A1, 27 July 2006
  21. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077367 A1, 27 July 2006
  22. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077366 A1, 27 July 2006
  23. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077365 A1, 27 July 2006
  24. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P. Indoles useful in the treatment of inflammation. WO 2006/077364 A1, 27 July 2006
  25. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123675 A1, 29 Dec 2005
  26. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123674 A1, 29 Dec 2005
  27. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/123673 A1, 29 Dec 2005
  28. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/005415 A1, 20 Jan 2005