Dr. Linda Supe

Dr. Linda Supe

Scientist

Curriculum Vitae

Education

PhD in chemistry, University of Rostock, Germany, 2014
Thesis: “Design and synthesis of 1H-pyrazolo[3,4-b]pyridine-3(2H)-ones and corresponding N-nucleosides-new purine isosters as potential drug-like scaffolds”
Supervisor: Prof. Dr.h.c.mult. P. Langer

Experience

Latvian Institute of Organic Synthesis
Research Scientist, 2014-present

University of Latvia, Faculty of Chemistry
PhD student, 2004-2009

Publications

  1. Jaunsleine, K.; Supe, L.; Spura, J.; van Beek, S.; Sandström, A.; Olsen, J.; Halleskog, C.; Bengtsson, T.; Mutule, I.; Pelcman, B. Development of Novel Β2-Adrenergic Receptor Agonists for the Stimulation of Glucose Uptake – The Importance of Chirality and Ring Size of Cyclic Amines. Bioorganic & Medicinal Chemistry Letters 2024, 97, 129562. DOI: 10.1016/j.bmcl.2023.129562.
  2. Kiamehr, M.; Moghaddam, F.M.; Mkrtchyan, S.; Semeniuchenko, V.; Supe, L.; Villinger, A.; Langer, P.; Laroshenko, V. O. “Tandem dinucleophilic cyclization of cyclohexane-1,3-diones with pyridinium salts” Beilst. J. Org. Chem. 20139, 1119-1126. DOI:10.3762/bjoc.9.124
  3. Iaroshenko, V. O.; Vilches-Herrera, M.; Gevorgyan, A.; Mkrtchyan, S.; Arakelyan, K.; Ostrovskyi, D.; Abbasi, M. S. A.; Supe, L.; Hakobyan, A.; Villinger, A.; Volochnyuk, D. M.; Tolmachev, A. ” Design, synthesis and transformation of some heteroannulated 3-aminopyridines – Purine isosteres with exocyclic nitrogen atom ” Tetrahedron 201369, 1217-1228. DOI:10.1016/j.tet.2012.11.026
  4. Iaroshenko, V. O.; Bunescu, A.; Spannenberg, A.; Supe, L.; Milyutina, M.; Langer, P. ” 3-Methoxalylchromones – Versatile reagents for the regioselective synthesis of functionalized 2,4′-dihydroxybenzophenones, potential UV-filters” Org. Biomol. Chem. 20119, 7554-7558. DOI10.1039/C1OB05931A
  5. Iaroshenko, V. O.; Mkrtchyan, S.; Ghazaryan, G.; Hakobyan, A.; Maalik, A.; Supe, L.; Villinger, A.; Tolmachev, A.; Ostrovskyi, D.; Sosnovskikh, V. Y.; Ghochikyan, T. V.; Langer, P. ”3-(Dichloroacetyl)chromone; A new building block for the synthesis of formylated purine isosteres: Design and Synthesis of Fused -(formyl)pyridines” Synthesis2011, 469-479. DOI: 10.1055/s-0030-1258364