Diastereoselective synthesis

Many pharmacologically relevant chemical compounds contain chiral amine functionality. Therefore the development of stereoselective methods for synthesis of chiral, non-racemic amines is of high importance in organic and pharmaceutical chemistry. Stereoselective synthesis employing Ellman’s chiral tert-butanesulfinamide reagent is among the most efficient ways to prepare chiral amines.

We are interested in the application of Ellman’s N-tert-butanesulfinyl chiral auxiliary in the development of new synthetic methods to access amines with multiple stereogenic centers.