Total synthesis

Research, Total synthesis

Total synthesis of diazonamide A in our laboratory is carried out in collaboration with professor Edwin Vedejs. After completion of the total synthesis the prepared highly cytotoxic natural product will be used in the design of structurally simplified analogs of diazonamide A as anti-cancer agents.

Diazonamide A
Diazonamide A

Publications

2. Mutule, I.; Kalnins, T.; Vedejs, E.; Suna, E. “Diazonamide Synthetic Studies. Reactivity of N-Unsubstituted Benzofuro[2,3-b]indolines” Chem. Heterocycl. Comp. 2015, 51, 613-620. PDF

1. Mutule, I.; Joo, B.; Medne, Z.; Kalnins, T.; Vedejs, E.; Suna, E. “Stereoselective Synthesis of the Diazonamide A Macrocyclic Core” J. Org. Chem. 2015, 80, 3058-3066. DOI: 10.1021/jo502941

Stereoselective Synthesis of the Diazonamide A Macrocyclic Core