Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors

Kinena, L.; Ozola, V. Chem. Heterocycl. Comp. 2020, 56, 60–66.

DOI: 10.1007/s10593-020-02623-6


A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory activity against plasmepsins I and II.