Koleda O., Sadauskis J., Antonenko D., Treijs E. J., Steberis R. D., Suna E. Beilstein J. Org. Chem. 2025, 21, 630–638.
DOI: 10.3762/bjoc.21.50
Abstract
The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N-acetylamino malonic acid monoesters is reported. The decarboxylative amidation under Hofer–Moest reaction conditions proceeds in an undivided cell under constant current conditions in aqueous acetonitrile and provides access to N-sulfonyl, N-benzoyl, and N-Boc-protected 2-aminoproline derivatives.