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# Edgars Suna Group

Laboratory of Advanced Technologies for Organic Synthesis

## Posts

- [March 2026](https://ospt.osi.lv/march-2026/) - Viktorija receives Solomon Hiller award for her PhD thesis. Congrats!
- [June 2026](https://ospt.osi.lv/june-2026/) - Undergraduate and Master’s students from our team have graduated from University of Latvia. Congrats!
- [64. Electrochemistry of Hypervalent Halogen Compounds](https://ospt.osi.lv/electrochemistry-of-hypervalent-halogen-compounds/) - Hypervalent halogens (I(III) and Br(III) derivatives) represent a versatile and effective class of reagents that are widely used in synthetic organic chemistry.
- [63. Stereospecific SuFEx reactivity of highly enantioenriched sulfondiimidoyl fluorides](https://ospt.osi.lv/stereospecific-sufex-reactivity-of-highly-enantioenriched-sulfondiimidoyl-fluorides/) - This work establishes sulfondiimidoyl fluorides as robust chiral SuFEx building blocks for asymmetric synthesis
- [62. Through-space cation–π quadrupole–monopole design enables selective suppression of third-order nonlinear optical Kerr effects](https://ospt.osi.lv/through-space-cation-π-quadrupole-monopole-design-enables-selective-suppression-of-third-order-nonlinear-optical-kerr-effects/) - These findings establish electrostatic through-space coupling as a general design principle for inverting the optical nonlinearity hierarchy in organic materials.
- [February 2026](https://ospt.osi.lv/february-2026/) - Congratulations to the latest PhD graduate - Vadims!
- [61. Investigation of structure, optical properties and chemical stability of the KL1421 pyridinium luminophore with high quantum yield](https://ospt.osi.lv/investigation-of-structure-optical-properties-and-chemical-stability-of-the-kl1421-pyridinium-luminophore-with-high-quantum-yield/) - This study reports on the synthesis, structure, and optical properties of a novel pyridinium luminophore (KL1421).
- [60. Electrochemical synthesis of cyclic biaryl λ3-bromanes from 2,2’-dibromobiphenyls](https://ospt.osi.lv/electrochemical-synthesis-of-cyclic-biaryl-λ3-bromanes-from-22-dibromobiphenyls/) - The electrochemical method provides access to a range of symmetrically and non-symmetrically substituted cyclic biaryl λ3-bromanes in moderate yields.
- [59. Chiral Epoxy-Imine Building Block for Diversity-Oriented Synthesis of Peptidomimetic Aspartic Protease Inhibitors](https://ospt.osi.lv/chiral-epoxy-imine-building-block-for-diversity-oriented-synthesis-of-peptidomimetic-aspartic-protease-inhibitors/) - Herein, we have designed a bifunctional building block for diversity-oriented step economy synthesis of anti-1,3-diaminopropan-2-ol derivatives.
- [58. GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity](https://ospt.osi.lv/grk-biased-adrenergic-agonists-for-the-treatment-of-type-2-diabetes-and-obesity/) - GRK-biased β2AR partial agonists are promising oral alternatives to injectable incretin mimetics used in the treatment of type 2 diabetes and obesity.
- [September 2025](https://ospt.osi.lv/september-2025/) - Daniels and Glebs won the awards for the best posters of 14th Paul Walden Symposium. Congrats!
- [December 2024](https://ospt.osi.lv/december-2-2/) - Kaspars' research has been named as one of the 10 major achievements in Latvian science this year!
- [57. Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters](https://ospt.osi.lv/entry-to-2-aminoprolines-via-electrochemical-decarboxylative-amidation-of-n‑acetylamino-malonic-acid-monoesters/) - The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N-acetylamino malonic acid monoesters is reported
- [56. S-Alkylation of sulfinamides with Zn-carbenoids: expanding stereoselective sulfoximine synthesis beyond NH derivatives](https://ospt.osi.lv/s-alkylation-of-sulfinamides-with-zn-carbenoids-expanding-stereoselective-sulfoximine-synthesis-beyond-nh-derivatives/) - We report an approach toward enantiopure N-substituted sulfoximines via direct stereoretentive S-alkylation of parent sulfinamides with zinc carbenoids
- [55. Tailoring Emission Lifetime for Dopant-Induced Phosphorescence](https://ospt.osi.lv/tailoring-emission-lifetime-for-dopant-induced-phosphorescence/) - We demonstrate that the RTP lifetime is directly proportional to intermolecular charge transfer (CT) properties of the crystalline bulk emitter.
- [July 2022](https://ospt.osi.lv/july-2022-2/) - Olesja and Glebs won the awards for the best posters of BOS 2022. Congrats!
- [January 2024](https://ospt.osi.lv/january-2024-1/) - Congratulations to the latest PhD graduate from our group - Olesja Koleda!
- [July 2024](https://ospt.osi.lv/july-2024/) - Arturs won the awards for the best poster of BOS 2024. Congrats!
- [November 2024](https://ospt.osi.lv/november-2024/) - Congrats to the latest PhD graduates from our group - Viktorija and Toms!
- [54. Impurity-Induced Phosphorescence in Purely Organic Materials](https://ospt.osi.lv/impurity-induced-phosphorescence-in-purely-organic-materials/) - This review aims at bridging the apparent knowledge gap by integrating prior understanding with the latest findings on the role of impurities in phosphorescence
- [53. Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide](https://ospt.osi.lv/development-of-potent-microtubule-targeting-agent-by-structural-simplification-of-natural-diazonamide/) - We demonstrate that truncation of heteroaromatic macrocycle in natural diazonamide A, combined with the replacement of the challenging-to-synthesize tetracyclic hemiaminal subunit by oxindole moiety leads to considerably less complex analogues with improved drug-like properties and nanomolar antiproliferative potency.
- [52. The Novel Adrenergic Agonist ATR-127 Targets Skeletal Muscle and Brown Adipose Tissue to Tackle Diabesity and Steatohepatitis](https://ospt.osi.lv/the-novel-adrenergic-agonist-atr-127-targets-skeletal-muscle-and-brown-adipose-tissue-to-tackle-diabesity-and-steatohepatitis/) - We here developed and evaluated the therapeutic potential of a novel β2-and β3-AR, named ATR-127, for the treatment of obesity and its associated metabolic perturbations in preclinical models.
- [51. Chiral 4-MeO-Pyridine (MOPY) Catalyst for Enantioselective Cyclopropanation: Attenuation of Lewis Basicity Leads to Improved Catalytic Efficiency](https://ospt.osi.lv/chiral-4-meo-pyridine-mopy-catalyst-for-enantioselective-cyclopropanation-attenuation-of-lewis-basicity-leads-to-improved-catalytic-efficiency-2/) - A rational design of Lewis base catalyst by fine-tuning of pyridine Lewis basicity has allowed for the development of chiral 4-MeO-pyridine (MOPY) catalyst for enantioselective cyclopropanation.
- [50. Development of novel β2-adrenergic receptor agonists for the stimulation of glucose uptake – The importance of chirality and ring size of cyclic amines](https://ospt.osi.lv/development-of-novel-β2-adrenergic-receptor-agonists-for-the-stimulation-of-glucose-uptake-the-importance-of-chirality-and-ring-size-of-cyclic-amines/) - β2-Adrenergic receptor (β2AR) agonists have been reported to stimulate glucose uptake (GU) by skeletal muscle cells and are therefore highly interesting as a possible treatment for type 2 diabetes (T2D).
- [49. Synthesis and Evaluation of Novel 5-O-(4-C-Aminoalkyl-β-D-ribofuranosyl) Apramycin Derivatives for the Inhibition of Gram-Negative Pathogens Carrying the Aminoglycoside Phosphotransferase(3′)-Ia Resistance Determinant](https://ospt.osi.lv/synthesis-and-evaluation-of-novel-5-o-4-c-aminoalkyl-β-d-ribofuranosyl-apramycin-derivatives-for-the-inhibition-of-gram-negative-pathogens-carrying-the-aminoglycoside-phosphotransferase3/) - New apramycin 5-O-β-d-ribofuranosides, or apralogs, carrying aminoalkyl branches at the ribofuranose 4-position possesing excellent activity for the inhibition of protein synthesis by wild-type bacterial ribosomes is reported.
- [47. Electrochemical Synthesis of Unnatural Amino Acids via Anodic Decarboxylation of N-Acetylamino Malonic Acid Derivatives](https://ospt.osi.lv/macrocyclic-peptidomimetic-plasmepsin-x-inhibitors-with-potent-in-vitro-and-in-vivo-antimalarial-activity-2/) - Herein, we disclose an electrochemical approach toward unnatural THF- and THP-containing amino acid derivatives that relies on anodic decarboxylation-intramolecular etherification of inexpensive and readily available N-acetylamino malonic acid monoesters under Hofer–Moest reaction conditions. The decarboxylative cyclization proceeds under constant current conditions in an undivided cell in an aqueous medium without any added base. A successful bioisosteric replacement of the 1-aminocyclohexane-1-carboxylic acid subunit by the THP-containing amino acid scaffold in cathepsin K inhibitor balicatib helped to reduce lipophilicity while retaining low nanomolar enzyme inhibitory potency and comparable microsomal stability.
- [46. Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity](https://ospt.osi.lv/macrocyclic-peptidomimetic-plasmepsin-x-inhibitors-with-potent-in-vitro-and-in-vivo-antimalarial-activity/) - We have developed an antimalarial lead compound 7k acting as a PMX inhibitor, which demonstrates proof of principle for an orally administered drug in a P. falciparum infection model in vivo. Further development of analogues with a simplified route to synthesis and improved PK properties is now needed in order to achieve a next-generation lead suitable for a single-dose antimalarial treatment regimen.
- [45. The emission efficiency of cationic solid state luminophores is directly proportional to the intermolecular charge transfer intensity](https://ospt.osi.lv/the-emission-efficiency-of-cationic-solid-state-luminophores-is-directly-proportional-to-the-intermolecular-charge-transfer-intensity/) - We demonstrate that the solid state photoluminescence quantum yield (Φ) of cationic luminophores is directly proportional to the charge transfer (CT) intensity within a network of molecules in the crystal lattice.
- [44. Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183](https://ospt.osi.lv/optimized-synthesis-of-indole-carboxylate-metallo-β-lactamase-inhibitor-ebl-3183/) - The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported.
- [43. Electrochemical Synthesis of Dimeric λ3-Bromane: Platform for Hypervalent Bromine(III) Compounds](https://ospt.osi.lv/electrochemical-synthesis-of-dimeric-λ3-bromane-platform-for-hypervalent-bromineiii-compounds/) - The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported.
- [42. Simple and scalable electrosynthesis of 1H-1-hydroxy-quinazolin-4-ones](https://ospt.osi.lv/simple-and-scalable-electrosynthesis-of-1h-1-hydroxy-quinazolin-4-ones/) - The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported.
- [41. Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)](https://ospt.osi.lv/synthesis-antibacterial-and-antiribosomal-activity-of-the-3c-aminoalkyl-modification-in-the-ribofuranosyl-ring-of-apralogs/) - The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported.
- [40. Electrochemistry and Reactivity of Chelation-stabilized Hypervalent Bromine(III) Compounds](https://ospt.osi.lv/electrochemistry-and-reactivity-of-chelation-stabilized-hypervalent-bromineiii-compounds/) - A fresh approach involves chelation-stabilized bromine(III) species which are conveniently prepared by electro-oxidation of parent bromoarenes.
- [39. Synthetic Approach toward Enantiopure Cyclic Sulfinamides](https://ospt.osi.lv/synthetic-approach-toward-enantiopure-cyclic-sulfinamides/) - A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective SN2′ cyclization/tert-Bu cleavage sequence.
- [38. Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors](https://ospt.osi.lv/imitation-of-β-lactam-binding-enables-broad-spectrum-metallo-β-lactamase-inhibitors/) - Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-β-lactamases (MBLs). Here we report the discovery and optimization of potent broad-spectrum MBL inhibitors.
- [37. N-Terminal Modification of Gly-His-Tagged Proteins with Azidogluconolactone](https://ospt.osi.lv/n-terminal-modification-of-gly-his-tagged-proteins-with-azidogluconolactone/) - Site-selective α-amino acylation of proteins with N-terminal Gly-HisTags using 6-azido-6-deoxy-glucono-1,5-lactone (6AGDL) is reported.
- [36. Intermolecular Charge-Transfer Luminescence by Self-Assembly of Pyridinium Luminophores in Solutions](https://ospt.osi.lv/intermolecular-charge-transfer-luminescence-by-self-assembly-of-pyridinium-luminophores-in-solutions/) - Intermolecular π+-π interactions promote self-assembly of individually non-luminescent protonated pyridine luminophores in solution, resulting in intermolecular charge-transfer type emission.
- [35. Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5′′- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes](https://ospt.osi.lv/synthesis-and-antibacterial-activity-of-propylamycin-derivatives/) - Propylamycin (4′-deoxy-4′-propylparomomycin) is a next generation aminoglycoside antibiotic that displays increased antibacterial potency over the parent, coupled with reduced susceptibility to resistance determinants and reduced ototoxicity in the guinea pig model.
- [34. Electrochemical Generation of Hypervalent Bromine(III) Compounds](https://ospt.osi.lv/electrochemical-generation-of-hypervalent-bromine-iii-compounds/) - In sharp contrast to hypervalent iodine(III) compounds, the isoelectronic bromine(III) counterparts have been little studied to date. This knowledge gap is mainly attributed to the difficult-to-control reactivity of λ3-bromanes as well as to their challenging preparation from the highly toxic and corrosive BrF3 precursor.
- [33. Acylative Dynamic Kinetic Resolution of Secondary Alcohols: Tandem Catalysis by HyperBTM and Bäckvall’s Ruthenium Complex](https://ospt.osi.lv/acylative-dynamic-kinetic-resolution-of-secondary-alcohols-tandem-catalysis-by-hyperbtm-and-backvalls-ruthenium-complex/) - Non-enzymatic dynamic kinetic resolution (DKR) of secondary alcohols by enantioselective acylation using an isothiourea-derived HyperBTM catalyst and racemization of slowly reacting alcohol by Bäckvall’s ruthenium complex is reported.
- [32. Aggregation induced emission in one easy step: pyridinium AIEgens and counter ion effect](https://ospt.osi.lv/aggregation-induced-emission-in-one-easy-step-pyridinium-aiegens-and-counter-ion-effect/) - Protonation of pyridines with a strong acid is a general and straightforward approach to achieve efficient aggregation induced emission (AIE) in structurally remarkably simple organic molecules that lack any of the conventional luminophores. The relationship between the nature of counter ion and the AIE efficiency is demonstrated. The superiority of the perchlorate counter ion is attributed to efficient stabilization of the key intermolecular π+–π interactions between neighboring luminophore molecules in the crystal lattice.
- [31. Structure-​activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues](https://ospt.osi.lv/structure-​activity-relationship-studies-on-the-inhibition-of-the-bacterial-translation-of-novel-odilorhabdins-analogues/) - A structure-​activity relationship (SAR) study of NOSO-​95179, a nonapeptide from the Odilorhabdin class of antibacterials, was performed by systematic variations of amino acids in positions 2 and 5 of the peptide. A series of non-​proteinogenic amino acids was synthesized in high enantiomeric purity from Williams' chiral diphenyloxazinone by highly diastereoselective alkylation or by Aldol-​type reaction. NOSO-​95179 analogs for SAR studies were prepd. using solid-​phase peptide synthesis. Inhibition of bacterial translation by each of the synthesized Odilorhabdin analogs was measured using an in vitro test. For the most efficient analogs, antibacterial efficacy was measured against two wild-​type Enterobacteriaceae (Escherichia coli and Klebsiella pneumoniae) and against an efflux defective E. coli strain (ΔtolC) to evaluate the impact of efflux on the antibacterial activity.
- [30. Aliphatic chain-containing macrocycles as diazonamide A analogs](https://ospt.osi.lv/aliphatic-chain-containing-macrocycles-as-diazonamide-a-analogs/) - Aliphatic alkyl chain-containing 12–14-membered macrocycles have been designed as structural analogs of antimitotic natural product diazonamide A. Macrocycles were synthesized from 5-bromooxazole in 7 to 9 linear steps using Ru-catalyzed ring-closing metathesis as the key transformation. Heat effect of binding to α,β-tubulin tetramer (T4-RB3 complex) has been measured for the synthesized macrocycles by isothermal titration calorimetry method.
- [29. Preparative scale synthesis of functionalized bioxazole](https://ospt.osi.lv/preparative-scale-synthesis-of-functionalized-bioxazole/) - Seven-step preparative scale synthesis of chiral, enantiomerically pure 2'-aminomethyl-2,4'-bioxazole has been accomplished from L-tert-Leu. The 2,4'-bioxazole subunit can be functionalized at position C-5' by a regioselective lithiation, followed by the reaction with a suitable electrophile. The C-5'-lithium intermediate can be also transmetalated into organozinc species and used in Pd-catalyzed Negishi cross coupling.
- [28. Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors](https://ospt.osi.lv/tetrahydroisoquinoline-based-non-peptidomimetic-plasmepsin-inhibitors/) - A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory activity against plasmepsins I and II.
- [27. Cation–π interactions secure aggregation induced emission of planar organic luminophores](https://ospt.osi.lv/cation-pi-interactions-secure-aggregation-induced-emission-of-planar-organic-luminophores/) - Intermolecular π+–π interactions between quaternary pyridinium or imidazolium cations and aromatic π systems achieves AIE in planar purely organic luminophores.
- [26. Simple and scalable electrochemical synthesis of 2,1-benzisoxazoles and quinoline N-oxides](https://ospt.osi.lv/simple-and-scalable-electrochemical-synthesis-of-21-benzisoxazoles-and-quinoline-n-oxides/) - Cathodic reduction of the nitro moiety and subsequent intramolecular cyclization affords different substituted 2,1-benzisoxazoles and quinoline N-oxides.
- [25. Aggregation induced emission by pyridinium–pyridinium interactions](https://ospt.osi.lv/aggregation-induced-emission-by-pyridinium-pyridinium-interactions/) - Non-covalent intermolecular interactions between pyridinium subunits in a crystal-state are an efficient means to accomplish aggregation induced emission and avoid aggregation caused quenching.
- [24. Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasm](https://ospt.osi.lv/mechanistic-aspects-of-maltotriose-conjugate-translocation-to-the-gram-negative-bacteria-cytoplasm/) - Here, we have characterized maltodextrin–fluorophore conjugates that can pass through both the outer and inner membranes mediated by components of the Escherichia coli maltose regulon.
- [23. Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D](https://ospt.osi.lv/peptidomimetic-plasmepsin-inhibitors-with-potent-anti-malarial-activity-and-selectivity-against-cathepsin-d/) - Guided by sequence alignment of Plms and Cat D, selectivity-inducing structural motifs were modified in the S3 and S4 sub-pocket occupying substituents of the hydroxyethylamine inhibitors. This resulted in potent anti-malarials with an up to 50-fold Plm IV/Cat D selectivity factor.
- [22. Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts](https://ospt.osi.lv/preparative-scale-synthesis-of-vedejs-chiral-dmap-catalysts/) - A scalable synthesis of chiral Vedejs-type DMAP catalysts is reported. The key step of the synthesis is amination of the enantiomerically pure 4-chloropyridine derivative using well-defined ZnCl2(amine)2 complexes.
- [20. Stereodivergent Synthesis of Pseudotabersonine Alkaloids](https://ospt.osi.lv/stereodivergent-synthesis-of-pseudotabersonine-alkaloids/)
- [19. Synthesis of Benzoxazoles Using Electrochemically Generated Hypervalent Iodine](https://ospt.osi.lv/synthesis-of-benzoxazoles-using-electrochemically-generated-hypervalent-iodine/)
- [18. Development of a Chiral DMAP Catalyst for the Dynamic Kinetic Resolution of Azole Hemiaminals](https://ospt.osi.lv/development-of-a-chiral-dmap-catalyst-for-the-dynamic-kinetic-resolution-of-azole-hemiaminals/)
- [17. Para-Selective Cu–catalyzed C–H Aryloxylation of Electron-rich Arenes and Heteroarenes](https://ospt.osi.lv/para-selective-cu-catalyzed-c-h-aryloxylation-of-electron-rich-arenes-and-heteroarenes/)
- [16. Copper-Catalyzed para–Selective C–H Amination of Electron-Rich Arenes](https://ospt.osi.lv/copper-catalyzed-para-selective-c-h-amination/)
- [15. Diazonamide Synthetic Studies. Reactivity of N-Unsubstituted Benzofuro[2,3-b]indolines](https://ospt.osi.lv/diazonamide-synthetic-studies/)
- [14. Stereoselective Synthesis of the Diazonamide A Macrocyclic Core](https://ospt.osi.lv/stereoselective-synthesis-of-the-diazonamide-a-macrocyclic-core/)
- [13. Synthesis of 9-Phenylacridines via Ortho-Lithiation–Cyclization Sequence](https://ospt.osi.lv/synthesis-of-9-phenylacridines-via-ortho-lithiation-cyclization-sequence/)
- [12. Copper-Catalyzed Intermolecular C-H Amination of (Hetero)arenes via Transient Unsymmetrical lambda3-Iodanes](https://ospt.osi.lv/copper-catalyzed-intermolecular-c-h-amination-of-heteroarenes/)
- [11. Diastereoselective Hydroxymethylation of Cyclic N–tert-Butanesulfinylketimines Using Methoxymethanol as Formaldehyde Source](https://ospt.osi.lv/diastereoselective-hydroxymethylation-of-cyclic-n-tert-butanesulfinylketimines/)
- [10. Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles](https://ospt.osi.lv/iodoacetic-acid-is-an-efficient-reagent-for-the-synthesis-of-amino-acid-derived-2-aminobenzimidazoles/)
- [9. Indirect C–H Azidation of Heterocycles via Copper-Catalyzed Regioselective Fragmentation of Unsymmetrical λ3-Iodanes](https://ospt.osi.lv/indirect-c-h-azidation-of-heterocycles/)
- [8. Transition-Metal-Catalyzed Acetoxylation of Heterocycles: All that Glitters is not Palladium (Highlight)](https://ospt.osi.lv/transition-metal-catalyzed-acetoxylation-of-heterocycles/)
- [7. Iodonium Salts Are Key Intermediates in Pd-Catalyzed Acetoxylation of Pyrroles](https://ospt.osi.lv/iodonium-salts-are-key-intermediates-in-pd-catalyzed-acetoxylation-of-pyrroles/)
- [6. Asymmetric Synthesis of 1,3-Diamines. II: Diastereoselective Reduction of Atropisomeric N–tert-Butanesulfinylketimines](https://ospt.osi.lv/asymmetric-synthesis-of-13-diamines-ii/)
- [5. Asymmetric Synthesis of 1,3-Diamines by Diastereoselective Reduction of Enantiopure N–tert-Butanesulfinylketimines: Unusual Directing Effects of the ortho-Substituent](https://ospt.osi.lv/asymmetric-synthesis-of-13-diamines/)
- [4. Catalytic Direct Acetoxylation of Indoles](https://ospt.osi.lv/catalytic-direct-acetoxylation-of-indoles/)
- [2. Arylzinc species by microwave assisted Grignard formation–transmetallation sequence: application in the Negishi coupling](https://ospt.osi.lv/arylzinc-species-by-microwave-assisted-grignard-formation/)
- [1. A convenient microwave assisted arylzinc generation-Negishi coupling protocol](https://ospt.osi.lv/microwave-assisted-arylzinc-generation/)
- [June 2024](https://ospt.osi.lv/june-2024-1/) - Undergraduate and Master’s students from our team have graduated from University of Latvia. Congrats!
- [June 2023](https://ospt.osi.lv/june-2023-1/) - Undergraduate and Master’s students from our team have graduated from University of Latvia. Congrats!
- [48. Pyrazolidinone-based peptidomimetic SARS-CoV-2 Mpro inhibitors](https://ospt.osi.lv/pyrazolidinone-based-peptidomimetic-sars-cov-2-mpro-inhibitors/) - Herein, we describe the investigation of β- and γ-lactams as electrophilic “warheads” for covalent binding to Cys145 of the Mpro active site.
- [October 2022](https://ospt.osi.lv/october-2022/) - Arturs recieves scholarship for PhD studies from University of Latvia Foundation. Congrats!
- [May 2023](https://ospt.osi.lv/may-2023-1/) - Linda spent two months working in prof. Tore Bengtsson group. Welcome back!
- [May 2023](https://ospt.osi.lv/may-2023-1-2/) - Linda spent two months working in prof. Christopher J. Schofield group. Welcome back!
- [May 2023](https://ospt.osi.lv/may-2023-1-2-2/) - Artis becomes associate professor of University of Latvia Faculty of Chemistry. Congrats!
- [February 2023](https://ospt.osi.lv/february/) - Prime Minister of Latvia Krišjānis Kariņš visits LIOS!
- [January 2023](https://ospt.osi.lv/january/) - Our group's work has been named as one of the 12 major achievements in Latvian science this year!
- [June 2022](https://ospt.osi.lv/june-2022-2-2/) - Olesja spent three months working in prof. S. R. Waldvogel group. Welcome back!
- [July 2022](https://ospt.osi.lv/july-2022/) - Kaspars Leduskrasts has successfully defended his PhD thesis. Congrats!
- [June 2022](https://ospt.osi.lv/june-2022-2-2-2/) - Artis spent four months working in Prof. A. C. Spivey's group. Welcome back!
- [June 2022](https://ospt.osi.lv/june-2022-2/) - Undergraduate and Master's students from our team have graduated from University of Latvia. Congratulations!
- [21. Azole‐based non‐peptidomimetic plasmepsin inhibitors](https://ospt.osi.lv/azole‐based-non‐peptidomimetic-plasmepsin-inhibitors/) - We report the development of novel azole‐based non‐peptidomimetic plasmepsin inhibitors that have been designed by bioisosteric substitution of the amide moiety in the Actelion amino‐piperazine inhibitors.
- [3. Microwave-assisted Heterocyclic Chemistry](https://ospt.osi.lv/microwave-assisted-heterocyclic-chemistry/)
- [December 2021](https://ospt.osi.lv/december-2/) - Igors's research has been named as one of the 10 major achievements in Latvian science this year!
- [December 2021](https://ospt.osi.lv/december/) - Igors and Glebs receive funding from Latvian Council of Science.
- [October 2021](https://ospt.osi.lv/october-2021-1/) - Arturs and Sabine received scholarships from University of Latvia Foundation. Congrats!
- [October 2021](https://ospt.osi.lv/october-2021-2/) - Viktorija and Glebs won the awards for the best posters of 12th Paul Walden Symposium. Congrats!
- [October 2020](https://ospt.osi.lv/october-2020/) - Students from our group receive scholarships from University of Latvia Foundation for 2020/2021 academic year. Congrats!
- [June 2021](https://ospt.osi.lv/june-2021/) - Undergraduate and Master's students from our team have successfully graduated from University of Latvia. Congrats!
- [November 2020](https://ospt.osi.lv/november-2020/) - The head of our laboratory Edgars, has been awarded the Order of the Three Stars (3rd class). Congratulations!
- [October 2019](https://ospt.osi.lv/october-2019/) - Students from our group receive scholarships from the University of Latvia Foundation.
- [June 2020](https://ospt.osi.lv/june-2020-2/) - Undergraduate and Master's students from our team have successfully graduated from University of Latvia. Congrats!
- [June 2020](https://ospt.osi.lv/june-2020-2-3/) - Happy Birthday to the head of our laboratory Edgars!
- [June 2020](https://ospt.osi.lv/june-2020-1-2/) - Dmitrijs has been elected principial scientist. Congrats!
- [May 2020](https://ospt.osi.lv/may-2020-1/) - Linda Kinena has successfully defended her PhD thesis. Congrats!
- [December 2019](https://ospt.osi.lv/december-2019-3/) - The research of our group members is among Latvian the most significant achievements in science.
- [December 2019](https://ospt.osi.lv/december-2019-2-2-2/) - Dmitrijs receives postdoctoral fellowship funded by ERDF. Congrats!
- [December 2019](https://ospt.osi.lv/december-2019-2-2/) - Artis receives postdoctoral fellowship funded by ERDF. Congrats!
- [December 2019](https://ospt.osi.lv/december-2019-2/) - Artis receives Solomon Hiller award for his PhD thesis. Congrats!
- [November 2019](https://ospt.osi.lv/november-2019/) - Our group members participate in the first LIOS scientific conference.
- [September 2019](https://ospt.osi.lv/september-2019/) - Our group members have participated in the poster session of 11th Paul Walden Symposium.
- [June 2019](https://ospt.osi.lv/june-2019/) - Undergraduate and Master's students from our team have successfully graduated from University of Latvia. Congrats!
- [August 2019](https://ospt.osi.lv/august-2019/) - This summer our team went hiking along Brasla river. What a wonderful adventure we experienced together!
- [May 2019](https://ospt.osi.lv/may-2019/) - Artis has succesfully defended his PhD thesis "Lewis Base Catalysts by Chiral DMAP species"
- [August 2018](https://ospt.osi.lv/august-2018/) - Igors receives Solomon Hiller award for his PhD thesis "C-H Functionalization of (Hetero)arenes".
- [November 2017](https://ospt.osi.lv/november-2017/) - Igors succesfully defended his PhD thesis “C-H Functionalization of (Hetero)arenes” at University of Latvia. Congratulations!
- [December 2018](https://ospt.osi.lv/december-2018/) - Rimants receives “Student of the year” award from University of Latvia.
- [November 2014](https://ospt.osi.lv/november-2014/)
- [July 2011](https://ospt.osi.lv/esoc-2011/) - Posters from our laboratory at the 17th European Symposium on Organic Chemistry 2011
- [June 2012](https://ospt.osi.lv/bos-2012/) - Posters from our laboratory at the Balticum Organicum Syntheticum 2012
- [July 2012](https://ospt.osi.lv/july-2012/) - Artis attended Gaussian workshop.
- [August 2012](https://ospt.osi.lv/august-2012/)
- [January 2013](https://ospt.osi.lv/january-2013/) - Marina PhD Thesis defense
- [April 2013](https://ospt.osi.lv/april-2013/)
- [May 2013](https://ospt.osi.lv/may-2013/) - 8th Paul Walden Symposium
- [October 2013](https://ospt.osi.lv/october-2013/)
- [January 2014](https://ospt.osi.lv/january-2014/)
- [June 2014](https://ospt.osi.lv/june-2014/)
- [March 2, 2015](https://ospt.osi.lv/february-2015/)
- [March 26, 2015](https://ospt.osi.lv/march-26-2015/)
- [October 27, 2015](https://ospt.osi.lv/october-27-2015/)

## Pages

- [Front page](https://ospt.osi.lv/)
- [Drug discovery projects on a contract research base (redirect)](https://ospt.osi.lv/drug-discovery/) - Development of mPGES-1 inhibitors for treatment of inflammatory pain Our laboratory has been involved in a long-term collaboration project with Swedish company BIOLIPOXaimed at the development of a medication for treatment of inflammatory pain, such as from rheumatoid arthritis. The goal of the project was design of selective inhibitor of membrane-bound prostaglandin (PG) E synthase (mPGES-1),
- [Development of synthetic routes for large scale synthesis (redirect)](https://ospt.osi.lv/development-of-synthetic-routes/) - Stereoselective synthesis of Doxapram A method for large-scale synthesis of generic drug Doxapram has been developed in collaboration with Galleon Pharma, Inc. (USA). Patents 1. Dax, S.L.; Ozola, V.; Krasikovs, A.; Suna, E. Novel Methods for Preparation of (+)-1-ethyl-4-[2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone and Salts Thereof. US2013/109854 A1, 5 May, 2013
- [Laboratory staff](https://ospt.osi.lv/laboratory-staff/)
- [Research](https://ospt.osi.lv/research-topics/)
- [Latest posts](https://ospt.osi.lv/news/)
- [Publications](https://ospt.osi.lv/publications/)
- [Edgars Suna group](https://ospt.osi.lv/ospt-group/)
- [Savējiem](https://ospt.osi.lv/savejiem/)
- [Former members](https://ospt.osi.lv/former-members/)
- [PhD students](https://ospt.osi.lv/phd-students/)
- [Our equipment](https://ospt.osi.lv/equipment/)
- [Internal](https://ospt.osi.lv/internal/)
- [Former PhD students](https://ospt.osi.lv/former-phd-students/)
- [Undergraduate students](https://ospt.osi.lv/undergraduate-students/)
- [MSc students](https://ospt.osi.lv/msc-students/)

## Portfolio items

- [Anticancer agents](https://ospt.osi.lv/research/anticancer-agents/) - We are interested in the development of the cancer chemotherapeutic agent with selective toxicity toward malignant cells.
- [Sulfur stereochemistry](https://ospt.osi.lv/research/sulfur-stereochemistry/) - We are interested in the application of Ellman’s N-tert-butanesulfinyl chiral auxiliary in the development of new enantioselective synthetic methods.
- [Antibacterials](https://ospt.osi.lv/research/antibacterials/)
- [Antimalarial agents](https://ospt.osi.lv/research/antimalarial-agents/) - In collaboration with the group of Prof. A. Jirgensons (Institute of Organic Synthesis), we are involved in the development of Plm inhibitors as antimalarial drugs.
- [Optical materials](https://ospt.osi.lv/research/optical-materials/) - We are participating in development of OLED technologies
- [Total synthesis](https://ospt.osi.lv/research/total-synthesis/) - Total synthesis of complex natural products is a superior way of training students in synthetic organic chemistry.
- [Organic electrosynthesis](https://ospt.osi.lv/research/organic-electrosynthesis/) - We are interested in the design and use of hypervalent I(III) species as a redox mediators.
- [Enantioselective Catalysis](https://ospt.osi.lv/research/enantioselective-catalysis/) - We are interested in the development of new chiral pyridines as Lewis base catalysts for applications in a wide range of enantioselective transformations.
- [Late-stage C-H functionalization](https://ospt.osi.lv/research/late-stage-c-h-functionalization/) - We have developed one-pot sequential multi-step approach to functionalization of aromatic and heterocyclic C–H bonds.
- [Antimalarial agents](https://ospt.osi.lv/research/antimalarial-agents/) - In collaboration with the group of Prof. A. Jirgensons (Institute of Organic Synthesis), we are involved in the development of Plm inhibitors as antimalarial drugs.

## Staff members

- [Oto Filipsons](https://ospt.osi.lv/members/oto-filipsons/) - (+371) 67014895 Curriculum Vitae Experience Latvian Institute of Organic Synthesis Laboratory Assistant, 2020-present
- [Toms Pulle](https://ospt.osi.lv/members/toms-pulle/) - (+371) 67014895 Curriculum Vitae Experience Latvian Institute of Organic Synthesis Laboratory Assistant, 2022-present
- [Matiss Martins Drava](https://ospt.osi.lv/members/matiss-martins-drava-2/) - (+371) 67014895 Curriculum Vitae Experience Latvian Institute of Organic Synthesis Laboratory Assistant, 2024-present
- [Raivis Davis Steberis](https://ospt.osi.lv/members/raivis-davis-steberis/) - (+371) 67014895 Curriculum Vitae Experience Latvian Institute of Organic Synthesis Laboratory Assistant, 2023-present
- [Prof. Dr. Edgars Suna](https://ospt.osi.lv/members/edgars-suna/)
- [Dr. Vadims Kovada](https://ospt.osi.lv/members/vadims-kovada/)
- [Dr. Viktorija Vitkovska](https://ospt.osi.lv/members/viktorija-vitkovska/)
- [Janis Sadauskis](https://ospt.osi.lv/members/janis-sadauskis-2/)
- [Dr. Igors Sokolovs](https://ospt.osi.lv/members/igors-sokolovs/)
- [Andrejs Savkins](https://ospt.osi.lv/members/andrejs-savkins/)
- [Arturs Mazarevics](https://ospt.osi.lv/members/arturs-mazarevics/)
- [Glebs Jersovs](https://ospt.osi.lv/members/glebs-jersovs/)
- [Mihail Kazak](https://ospt.osi.lv/members/mihail-kazak/)
- [Merija Agnese Meiberga](https://ospt.osi.lv/members/merija-agnese-meiberga/)
- [Dzonatans Miks Melgalvis](https://ospt.osi.lv/members/dzonatans-miks-melgalvis/)
- [Edvards Janis Treijs](https://ospt.osi.lv/members/edvards-janis-treijs/)
- [Sabine Kastaljana](https://ospt.osi.lv/members/sabine-kastaljana/)
- [Katrina Prane](https://ospt.osi.lv/members/katrina-prane/)
- [Arturs Raimonds Feldmanis](https://ospt.osi.lv/members/arturs-raimonds-feldmanis/)
- [Krista Jaunsleine](https://ospt.osi.lv/members/krista-jaunsleine/)
- [Dr. Dmitrijs Lubriks](https://ospt.osi.lv/members/dmitrijs-lubriks/)
- [Rihards Kluga](https://ospt.osi.lv/members/rihards-kluga/)
- [Dr. Linda Supe](https://ospt.osi.lv/members/linda-supe/) - (+371) 67014895 Curriculum Vitae Education PhD in chemistry, University of Rostock, Germany, 2014 Thesis: “Design and synthesis of 1H-pyrazolo[3,4-b]pyridine-3(2H)-ones and corresponding N-nucleosides-new purine isosters as potential drug-like scaffolds” Supervisor: Prof. Dr.h.c.mult. P. Langer Experience Latvian Institute of Organic Synthesis Research Scientist, 2014-present University of Latvia, Faculty of Chemistry PhD student, 2004-2009 Publications Jaunsleine, K.; Supe, L.;
- [Dr. Kaspars Leduskrasts](https://ospt.osi.lv/members/kaspars-leduskrasts/) - (+371) 67014895 Curriculum Vitae Education PhD in chemistry, University of Latvia, 2022 Thesis: “Intermolecular interactions in the design of solid state luminophores” Supervisor: Prof. Dr. E. Suna MSc in chemistry, University of Latvia, 2014 Thesis: “Reductive Elimination from Pd(IV) Complexes” Supervisor: Prof. E. Suna Experience Latvian Institute of Organic Synthesis Research Assistant, 2014-present Laboratory Assistant,
- [Dr. Artis Kinens](https://ospt.osi.lv/members/artis-kinens/)
- [Martins Priede](https://ospt.osi.lv/members/martins-priede/) - (+371) 67014895 Curriculum Vitae Education MSc in chemistry, University of Latvia, 2010 Thesis: “Dehydration reactions of symmetrical alcohols in ionic liquids” Supervisor: Asoc. Prof. A. Priksane Experience Latvian Institute of Organic Synthesis Research Assistant, 2009-present University of Latvia Laboratory Assistant, 2006-2009 Publications Kazak, M.; Priede, M.; Shubin, K.; Bartrum, H. E.; Poisson, J.-F.; Suna, E.
- [Dr. Anete Parkova](https://ospt.osi.lv/members/anete-parkova-2/)
- [Matiss Bojars](https://ospt.osi.lv/members/matiss-bojars/) - (+371) 67014895 Curriculum Vitae Experience Latvian Institute of Organic Synthesis Laboratory Assistant, 2020-2023 Ruhr-Universität Bochum (Germany) ERASMUS exchange student, April 2022-August 2022 Publications Jersovs, G.; Bojars, M.; Donets, P. A.; Suna, E. “Synthetic Approach toward Enantiopure Cyclic Sulfinamides” Org. Lett. 2022, 24, 4625–4629. DOI: 10.1021/acs.orglett.2c01738
- [Darja Antonenko](https://ospt.osi.lv/members/darja-antonenko/) - (+371) 67014895 Curriculum Vitae Experience Latvian Institute of Organic Synthesis Laboratory Assistant, 2023-present
- [Daniels Jelisejevs](https://ospt.osi.lv/members/daniels-jelisejevs/)
- [Andrejs Petuskovs](https://ospt.osi.lv/members/andrejs-petuskovs/)
- [Niks Freimanis](https://ospt.osi.lv/members/niks-freimanis/)
- [Maris Bazulis](https://ospt.osi.lv/members/maris-bazulis/)
- [Julija Bariseva](https://ospt.osi.lv/members/julija-barisheva/)
- [Dr. Olesja Koleda](https://ospt.osi.lv/members/olesja-koleda/)
- [Dr. Toms Kalnins](https://ospt.osi.lv/members/toms-kalnins/)
- [Dr. Linda Kinena](https://ospt.osi.lv/members/linda-kinena/)
- [Rimants Zogota](https://ospt.osi.lv/members/rimants-zogota/)
- [Aldis Janis Pivars](https://ospt.osi.lv/members/aldis-janis-pivars-1/)
- [Dr. Ilga Mutule](https://ospt.osi.lv/members/ilga-mutule/)
- [Dr. Vita Ozola](https://ospt.osi.lv/members/vita-ozola/)
- [Dr. Marina Martjuga](https://ospt.osi.lv/members/marina-martjuga/)
- [Dr. Andrejs Krasikovs](https://ospt.osi.lv/members/andrejs-krasikovs/)
- [Empty](https://ospt.osi.lv/members/empty/)
- [Nauris Narvaiss](https://ospt.osi.lv/members/nauris-narvaiss/)
- [Janis Briska](https://ospt.osi.lv/members/janis-briska/)
- [Simonas Balkaitis](https://ospt.osi.lv/members/simonas-balkaitis/)
- [Haralds Baunis](https://ospt.osi.lv/members/haralds-baunis/)
- [Marcis Sejejs](https://ospt.osi.lv/members/marcis-sejejs/)
- [Andrejs Sisulins](https://ospt.osi.lv/members/andrejs-sisulins/)
- [Toms Izmailovs](https://ospt.osi.lv/members/toms-izmailovs/)
- [Beatrise Berzina](https://ospt.osi.lv/members/beatrise-berzina/)
- [Anna Vasilevska](https://ospt.osi.lv/members/anna-vasilevska/)
- [Dr. Galina Razvadovska](https://ospt.osi.lv/members/galina-shuleva/)
- [Maija Kurtenoka](https://ospt.osi.lv/members/maija-kurtenoka/)
- [Zane Medne](https://ospt.osi.lv/members/zane-medne/)
- [Ksenija Denistsik](https://ospt.osi.lv/members/ksenija-denistsik/)
- [Dr. Kirill Shubin](https://ospt.osi.lv/members/kirill-shubin/)
- [Julija Kudrjasova](https://ospt.osi.lv/members/julija-kudrjasova/)
- [Dr. Elina Priede](https://ospt.osi.lv/members/elina-priede/)
- [Jevgenijs Kuzmins](https://ospt.osi.lv/members/jevgenijs-kuzmins/)
- [Dr. Eriks Palitis](https://ospt.osi.lv/members/eriks-palitis/)
- [Eriks Bite](https://ospt.osi.lv/members/eriks-bite/)
- [Dr. Dmitrijs Shabashovs](https://ospt.osi.lv/members/dmitrijs-shabashovs/)
- [Dr. Andrey Shchipalkin](https://ospt.osi.lv/members/andrey-shchipalkin/)

## Categories

- [Uncategorized](https://ospt.osi.lv/category/uncategorized/)
- [Conference](https://ospt.osi.lv/category/conference/)
- [Visits](https://ospt.osi.lv/category/visits/)
- [PhD Thesis](https://ospt.osi.lv/category/phd-thesis/)
- [Awards](https://ospt.osi.lv/category/awards/)
- [Members](https://ospt.osi.lv/category/members/)
- [Publications](https://ospt.osi.lv/category/publications/)
- [News](https://ospt.osi.lv/category/news/)
- [Antimalarial agents](https://ospt.osi.lv/category/publications/antimalarial-agents/)
- [Anticancer agents](https://ospt.osi.lv/category/publications/anticancer-agents/)
- [Antibacterials](https://ospt.osi.lv/category/publications/antibacterials/)
- [Material science](https://ospt.osi.lv/category/publications/material-science/)
- [Total synthesis](https://ospt.osi.lv/category/publications/total-synthesis/)
- [Organic electrosynthesis](https://ospt.osi.lv/category/publications/organic-electrosynthesis/)
- [Sulfur stereochemistry](https://ospt.osi.lv/category/publications/sulfur-stereochemistry/)
- [Enantioselective catalysis](https://ospt.osi.lv/category/publications/enantioselective-catalysis/)
- [Transition metal catalysis](https://ospt.osi.lv/category/publications/transition-metal-catalysis/)
- [Group events](https://ospt.osi.lv/category/group-events/)

## Categories

- [C-H functionalization](https://ospt.osi.lv/research-cat/c-h-functionalization/)
- [Enantioselective catalysis](https://ospt.osi.lv/research-cat/enantioselective-catalysis/)
- [Total synthesis](https://ospt.osi.lv/research-cat/total-synthesis/)
- [Sulfur stereochemistry](https://ospt.osi.lv/research-cat/sulfur-stereochemistry/)
- [Research](https://ospt.osi.lv/research-cat/research/)
- [Organic electrosynthesis](https://ospt.osi.lv/research-cat/organic-electrosynthesis/)
- [Optical materials](https://ospt.osi.lv/research-cat/optical-materials/)
- [Synthetic methodologies](https://ospt.osi.lv/research-cat/synthetic-methodologies/)
- [Medicinal chemistry](https://ospt.osi.lv/research-cat/medicinal-chemistry/)
- [Antibacterials](https://ospt.osi.lv/research-cat/antibacterials/)
- [Anti-cancer agents](https://ospt.osi.lv/research-cat/anti-cancer-agents/)
- [Antimalarial agents](https://ospt.osi.lv/research-cat/antimalarial-agents/)

## Departments

- [Laboratory Staff](https://ospt.osi.lv/members-cat/laboratory-staff/)
- [PhD student](https://ospt.osi.lv/members-cat/phd-student/)
- [MSc student](https://ospt.osi.lv/members-cat/msc-student/)
- [Former PhD student](https://ospt.osi.lv/members-cat/former-phd-student/)
- [Former member](https://ospt.osi.lv/members-cat/former-member/)
- [Head of Laboratory](https://ospt.osi.lv/members-cat/head-of-laboratory/)
- [Project Leader](https://ospt.osi.lv/members-cat/project-leader/)
- [Scientist](https://ospt.osi.lv/members-cat/scientist/)
- [Staff](https://ospt.osi.lv/members-cat/staff/)

## Positions

- [Principial Scientist](https://ospt.osi.lv/members-tag/principial-scientist/)
- [Research Scientist](https://ospt.osi.lv/members-tag/research-scientist/)
- [Research Assistant](https://ospt.osi.lv/members-tag/research-assistant/)
- [Laboratory Assistant](https://ospt.osi.lv/members-tag/laboratory-assistant/)
- [Laboratory Asisstant](https://ospt.osi.lv/members-tag/laboratory-asisstant/)
- [Principal Scientist](https://ospt.osi.lv/members-tag/principal-scientist/)