Dr. Dmitrijs Lubriks

Dr. Dmitrijs Lubriks

Former member, Former PhD student

Curriculum Vitae

Education

PhD in chemistry, Riga Technical University, 2015
Thesis: “Discovery of mPGES-1 inhibitors. Development of methods for C-H acetoxylation and amination of (hetero)arenes”
Supervisor: Prof. E. Suna

MSc in chemistry, Riga Technical University, 2007
Thesis: “Synthesis of polyfunctionalized indolylmagnesium species”
Supervisor: Prof. E. Suna

Experience

Latvian Institute of Organic Synthesis
Research Scientist, 2015-present
Research Assistant, 2007-2015
Laboratory Assistant, 2002-2007

Publications

  1. Lubriks, D.; Haldimann, K.; Kiliç, F.; Hartmann, M.; Böttger, E. C.; Hobbie, S. N.; Suna, E.; Crich, D. “Synthesis and Evaluation of Novel 5‐O‐(4‐C‐Aminoalkyl‐β‐D‐ribofuranosyl) Apramycin Derivatives for the Inhibition of Gram‐Negative Pathogens Carrying the Aminoglycoside Phosphotransferase(3′)‐Ia Resistance Determinant” Helv. Chim. Acta 2023, e202300138. DOI: 10.1002/hlca.202300138
  2. Lubriks, D.; Haldimann, K.; Hobbie, S. N.; Vasella, A.; Suna, E.; Crich, D. “Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)” Antibiotics 2023, 12, 25–39. DOI: 10.3390/antibiotics12010025
  3. Brem, J.; Panduwawala, T.; Hansen, J. U.; Hewitt, J.; Liepins, E.; Donets, P.; Espina, L.; Farley, A. J. M.; Shubin, K; Campillos, G. G.; Kiuru, P.; Shishodia, S.; Krahn, D.; Leśniak, R. K.; Schmidt (Adrian), J.; Calvopiña, K.; Turrientes, M. C.; Kavanagh, M. E.; Lubriks, D.; Hinchliffe, P.; Langley, G. W.; Aboklaish, A. F.; Eneroth, A.; Backlund, M.; Baran, A. G.; Nielsen, E. I.; Speake, M.; Kuka, J.; Robinson, J.; Grinberga, S.; Robinson, L.; McDonough, M. A.; Rydzik, A. M.; Leissing, T. M.; Jimenez-Castellanos, J. C.; Avison, M. B; Pinto, S. S.; Pannifer, A. D.; Martjuga, M.; Widlake, E.; Priede, M.; Navratilova, I. H.; Gniadkowski, M.; Belfrage, A. K.; Brandt, P.; Yli-Kauhaluoma, j.; Bacque, E.; Page, M. G. P.; Björkling, F.; Tyrrell, J. M.; Spencer, J.; Lang, P. A.; Baranczewski, P.; Cantón, R.; McElroy, S. P.; Jones, P. S.; Baquero, F.; Suna, E.; Morrison, A.; Walsh, T. R.; Schofield, C. J. “Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors” Nat. Chem 2022, 14, 15–24. DOI: 10.1038/s41557-021-00831-x
  4. Lubriks, D.; Zogota, R.; Sarpe, V. A.; Matsushita, T.; Sati, G.C.; Haldimann, K.; Gysin, M.; Böttger, E.C.; Vasella, A.; Suna, E.; Hobbie, S.N.; Crich, D. “Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5′′- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes” ACS Infect. Dis. 2021, 7, 2413–2424 DOI: 10.1021/acsinfecdis.1c00158
  5. Dumont, E.; Vergalli, J.; Pajovic, J.; Bhamidimarri, S. P.; Morante, K.; Wang, J.; Lubriks, D.; Suna, E.; Stavenger, R. A.; Winterhalter, M.; Refregiers, M.; Pages, J. M. “Mechanistic aspects of maltotriose-conjugate
    translocation to the Gram-negative bacteria cytoplasm” Life Science Alliance 2019, 2, e201800242. DOI: 10.26508/lsa.201800242
  6. Sokolovs, I.; Lubriks, D.; Suna, E. “Copper-Catalyzed Intermolecular C-H Amination of (Hetero)arenes via Transient Unsymmetrical lambda3-Iodanes”  J. Am. Chem. Soc. 2014136, 6920–6928. DOI: 10.1021/ja502174d
  7. Lubriks, D.; Sokolovs, I.; Suna, E. “Indirect C–H Azidation of Heterocycles via Copper-Catalyzed Regioselective Fragmentation of Unsymmetrical λ3-Iodanes” J. Am. Chem. Soc. 2012134, 15436-15442DOI: 10.1021/ja305574k
  8. Lubriks, D.; Sokolovs, I.; Suna, E. “Iodonium Salts Are Key Intermediates in Pd-Catalyzed Acetoxylation of Pyrroles” Org. Lett. 201113, 4324-4327. DOI: 10.1021/ol201665c

Patents

  1. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. Imidazo(4,5-b)pyridine-6-carboxamides as anti-inflammatory agents. WO2012/076674 A1, 14 June, 2012
  2. Priepke, H.; Kuelzer, R.; Mack, J.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. 2-Aminobenz imidazole derivatives useful in the treatment of inflammation WO2012/076672 A1, 14 June, 2012
  3. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna, E. 2-(Arylamino)-3H-imidazo-[4,5-b]-pyridine-6-carboxamide derivatives and their use as MPGES-1 inhibitors. WO2012/022792 A1, 23 February, 2012
  4. Pfau, R.; Arndt, K.; Doods, H.; Klinder, K.; Kuelzer, R.; Lubriks, D.; Mack, J.; Pelcman, B.; Priepke, H.; Rönn, R.; Stenkamp, D.; Suna, E. 3H-Imidazo-[4,5-c]-pyridine-6-carboxamides as anti-inflammatory agents. WO2010/100249 A1, 10 September, 2010