Prof. Dr. Edgars Suna

Prof. Dr. Edgars Suna

Head of Laboratory

Curriculum Vitae

Education

PhD in chemistry, University of Latvia, 1999
Thesis: “Chiral 1,2,3,4-Tetrahydroisoquinolines: Synthesis and Use in Enantioselective Protonation”
Supervisors: Prof. E. Vedejs, Dr. P. Trapencieris

Experience

Latvian Institute of Organic Synthesis
Principal Scientist, 2006-present
Head of Laboratory, 2003-present
Researcher, 1999-2006
Research Assistant, 1997-1999
Laboratory Assistant, 1990-1995

University of Wisconsin-Madison, USA
Research Assistant, 1996, 1998
(advisor Prof. E. Vedejs)

Riga Technical University
Lecturer, 2002-2006
Docent, 2006-2018
Visiting Professor, 2018-present

University of Latvia
Associate Professor, 2008-2013
Professor of Chemistry, 2013-present

Honors and Awards

Commander of the Order of the Three Stars, 2020
Walter Zapp prize
, Latvian Academy of Sciences, Latvian Patent Office and Minox GmbH (Germany), 2017
Award from Ministry of Science and Education, 2017
Full Member Latvian Academy of Sciences, 2014
Gustavs Vanags Prize, Latvian Academy of Sciences, 2014
Paul Walden Medal, Riga Technical University, 2013
Latvian Academy of Sciences and Grindex, Ltd Award for Young Scientist, year 1998

Invited Lectures and Oral Conference Presentations

  1. 7th International Conference on Hypervalent Iodine Chemistry, Stockholm, Sweden (June 25-28, 2023)
  2. The 2nd Drug Discovery Conference, Riga, Latvia (September 22-24, 2022)
  3. Markovnikov Congress on Organic Chemistry, Moscow-Kazan, Russia (June 21-28, 2019)
  4. The 4th World Congress of Latvian Scientists, Riga, Latvia (June 18-20, 2018)
  5. Leibniz Institute for Catalysis, Rostock, Germany (May 13, 2016)
  6. 251st American Chemical Society National Meeting, San-Diego, USA (March 13-17, 2016)
  7. Heterocycles in Bio-organic Chemistry 2013,  Riga, Latvia (May 27-30, 2013)
  8. 8th Paul Walden Symposium, Riga, Latvia (May 13-14, 2013)
  9. Balticum Organicum Syntheticum 2010, Riga, Latvia (June 27-30, 2010)
  10. 7th Asian Chemical Congress, Hiroshima, Japan (May 16-20, 1997)

Publications

Publications

  1. Kluga, R.; Kinens, A.; Suna, E. “Chiral 4-MeO-Pyridine (MOPY) Catalyst for Enantioselective Cyclopropanation: Attenuation of Lewis Basicity Leads to Improved Catalytic Efficiency” Chem. Eur. J. 2024, e202301136. DOI: 10.1002/chem.202301136
  2. Lubriks, D.; Haldimann, K.; Kiliç, F.; Hartmann, M.; Böttger, E. C.; Hobbie, S. N.; Suna, E.; Crich, D. “Synthesis and Evaluation of Novel 5‐O‐(4‐C‐Aminoalkyl‐β‐D‐ribofuranosyl) Apramycin Derivatives for the Inhibition of Gram‐Negative Pathogens Carrying the Aminoglycoside Phosphotransferase(3′)‐Ia Resistance Determinant” Helv. Chim. Acta 2023, e202300138. DOI: 10.1002/hlca.202300138
  3. Koleda, O.; Prane, K.; Suna, E. “Electrochemical Synthesis of Unnatural Amino Acids via Anodic Decarboxylation of N -Acetylamino Malonic Acid Derivatives” Org. Lett. 2023, 25, 7958-7962. DOI: 10.1021/acs.orglett.3c02687
  4. Lubriks, D.; Haldimann, K.; Kiliç, F.; Hartmann, M.; Böttger, E. C.; Hobbie, S. N.; Suna, E.; Crich, D. “Synthesis and Evaluation of Novel 5‐O‐(4‐C‐Aminoalkyl‐β‐D‐ribofuranosyl) Apramycin Derivatives for the Inhibition of Gram‐Negative Pathogens Carrying the Aminoglycoside Phosphotransferase(3’)‐Ia Resistance Determinant” Helv. Chimica Acta 2023, e202300138. DOI: 10.1002/hlca.202300138
  5. Kovada, V.; Withers-Martinez, C.; Bobrovs, R.; Ce̅rule, H.; Liepins, E.; Grinberga, S.; Hackett, F.; Collins, C. R.; Kreicberga, A.; Jiménez-Díaz, M. B.; Angulo-Barturen, I.; Rasina, D.; Suna, E.; Jaudzems, K.; Blackman, M. J.; Jirgensons, A. “Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity” J. Med. Chem.2023, 66,10658–10680. DOI: 10.1021/acs.jmedchem.3c00812
  6. Leduskrasts, K.; Kinens, A.; Suna, E. “The emission efficiency of cationic solid state luminophores is directly proportional to the intermolecular charge transfer intensity” Chem. Commun. 2023,59, 6905-6908. DOI: 10.1039/d3cc01674a
  7. Sokolovs, I.; Suna, E. “Electrochemical Synthesis of Dimeric λ3-Bromane: Platform for Hypervalent Bromine(III) Compounds” Org. Lett. 2023, 25, 2047–2052. DOI: 10.1021/acs.orglett.3c00405
  8. Koleda, O.; Prenzel, T,; Winter, J.; Hirohata, T.; Gálvez-Vázquez, J.; Schollmeyer, D.; Inagi, S.; Suna, E.; Waldvogel, S. R. “Simple and scalable electrosynthesis of 1H-1-hydroxy-quinazolin-4-ones” Chem. Sci. 2023, 14, 2669-2675. DOI: 10.1039/D3SC00266G
  9. Lubriks, D.; Haldimann, K.; Hobbie, S. N.; Vasella, A.; Suna, E.; Crich, D. “Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)” Antibiotics 2023, 12, 25–39. DOI: 10.3390/antibiotics12010025
  10. Baran, A.; Kuzmins, J.; Kuznecovs, J.; Farley, A., J., M.; Panduwawala, T.; Parkova, A.; Donets, P., A.; Brem, J.; Suna, E.; Schofield, C., J.; Shubin, K. “Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183” Org. Process Res. Dev. 2023, 27, 692–706. DOI:10.1021/acs.oprd.3c00002
  11. Jersovs, G.; Bojars, M.; Donets, P. A.; Suna, E. “Synthetic Approach toward Enantiopure Cyclic Sulfinamides” Org. Lett. 2022, 24, 4625–4629. DOI: 10.1021/acs.orglett.2c01738
  12. Mohebbati, N.; Sokolovs, I.; Woite, P.; Lõkov, M.; Parman, E.; Ugandi, M.; Leito, I.; Roemelt, M.; Suna, E.; Francke, R.“Electrochemistry and Reactivity of Chelation‐stabilized Hypervalent Bromine(III) Compounds” Chem-Eur. J. 2022, 28, e202200974. DOI: 10.1002/chem.202200974
  13. Brem, J.; Panduwawala, T.; Hansen, J. U.; Hewitt, J.; Liepins, E.; Donets, P.; Espina, L.; Farley, A. J. M.; Shubin, K; Campillos, G. G.; Kiuru, P.; Shishodia, S.; Krahn, D.; Leśniak, R. K.; Schmidt (Adrian), J.; Calvopiña, K.; Turrientes, M. C.; Kavanagh, M. E.; Lubriks, D.; Hinchliffe, P.; Langley, G. W.; Aboklaish, A. F.; Eneroth, A.; Backlund, M.; Baran, A. G.; Nielsen, E. I.; Speake, M.; Kuka, J.; Robinson, J.; Grinberga, S.; Robinson, L.; McDonough, M. A.; Rydzik, A. M.; Leissing, T. M.; Jimenez-Castellanos, J. C.; Avison, M. B; Pinto, S. S.; Pannifer, A. D.; Martjuga, M.; Widlake, E.; Priede, M.; Navratilova, I. H.; Gniadkowski, M.; Belfrage, A. K.; Brandt, P.; Yli-Kauhaluoma, j.; Bacque, E.; Page, M. G. P.; Björkling, F.; Tyrrell, J. M.; Spencer, J.; Lang, P. A.; Baranczewski, P.; Cantón, R.; McElroy, S. P.; Jones, P. S.; Baquero, F.; Suna, E.; Morrison, A.; Walsh, T. R.; Schofield, C. J. “Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors” Nat. Chem 2022, 14, 15–24. DOI: 10.1038/s41557-021-00831-x
  14. Brune,K. D.; Liekniņa, I.; Sutov, G.; Morris, A. R.; Jovicevic, D.; Kalniņš, G.; Kazāks, A.; Kluga, R.; Kastaljana, S.; Zajakina, A.; Jansons, J.; Skrastiņa, D.; Spunde, K.; Cohen, A. A.; Bjorkman, P. J.; Morris, H. R.; Suna, E.; Tārs, K. “N-Terminal Modification of Gly-His-Tagged Proteins with Azidogluconolactone” ChemBioChem 2021, 22, 3199-3207. DOI: 10.1002/cbic.202100381
  15. Leduskrasts, K.; Suna, E. “Intermolecular Charge-Transfer Luminescence by Self-Assembly of Pyridinium Luminophores in Solutions” ChemistryOpen 2021, 10, 1081-1086. DOI: 10.1002/open.202100191
  16. Sokolovs, I.; Mohebbati, N.; Francke, R.; Suna, E. “Electrochemical Generation of Hypervalent Bromine(III) Compounds” Angew. Chem. Int. Ed. 2021, 60, 15832–15837. DOI: 10.1002/anie.202104677
  17. Lubriks, D.; Zogota, R.; Sarpe, V. A.; Matsushita, T.; Sati, G.C.; Haldimann, K.; Gysin, M.; Böttger, E.C.; Vasella, A.; Suna, E.; Hobbie, S.N.; Crich, D. “Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5′′- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes” ACS Infect. Dis. 2021, 7, 2413–2424 DOI: 10.1021/acsinfecdis.1c00158
  18. Kinens, A.; Balkaitis, S.; Ahmad, O. K.; Piotrowski, D. W.; Suna, E. “Acylative Dynamic Kinetic Resolution of Secondary Alcohols: Tandem Catalysis by HyperBTM and Bäckvall’s Ruthenium Complex” J. Org. Chem. 2021, 86, 7189–7202.  DOI: 10.1021/acs.joc.1c00545
  19. Leduskrasts, K.; Suna, E. ” Aggregation induced emission in one easy step: pyridinium AIEgens and counter ion effect ” RSC Advances 2020, 10, 38107-38113. DOI: 10.1039/D0RA07137D
  20. Loza, E.; Sarciaux, M.; Ikaunieks, M.; Katkevics, M.; Kukosha, T.; Trufilkina, N.; Ryabova, V.; Shubin, K.; Pantel, L.; Serri, M.; Huseby, D. L.; Cao, S.; Yadav, K.; Hjort, K.; Hughes, D.; Gualtieri, M.; Suna, E.; Racine, E. “Structure-Activity Relationship Studies on the Inhibition of the Bacterial Translation of Novel Odilorhabdins Analogues” Bioorg. Med. Chem. 2020, 28, 115469. DOI: 10.1016/j.bmc.2020.115469
  21. Vitkovska, V.; Zogota, R.; Kalnins, T.; Zelencova, D.; Suna, E. “Aliphatic chain-containing macrocycles as diazonamide A analogs” Chem. Heterocycl. Comp., 2020, 56, 586–602. DOI: 10.1007/s10593-020-02704-6
  22. Kazak, M.; Vasilevska, A.; Suna, E. “Preparative scale synthesis of functionalized bioxazole” Chem. Heterocycl. Comp., 2020, 56, 355–364. DOI: 10.1007/s10593-020-02667-8
      1. Leduskrasts, K.; Kinens, A.; Suna, E. “Cation–π interactions secure aggregation induced emission of planar organic luminophores” Chem. Commun., 2019, 55, 12663-12666. DOI: 10.1039/C9CC06829E
      2. Rodrigo, E.; Baunis, H.; Suna, E.; Waldvogel, S., R. “Simple and scalable electrochemical synthesis of 2,1-benzisoxazoles and quinoline N-oxides” Chem. Commun., 2019, 55, 12255-1225.DOI: 10.1039/C9CC06054E
      3. Grandane, A.; Longowitz, L.; Roolf, C.; Spannenberg, A.; Escobar, H. M.; Junghanss, C.; Suna, E.; Werner, T. “Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones” J. Org. Chem. 2019, 84, 1320–1329. DOI: 10.1021/acs.joc.8b02789
      4. Leduskrasts, K.; Suna, E. “Aggregation induced emission by pyridinium–pyridinium interactions” RSC Advances 2019, 9, 460-465. DOI: 10.1039/C8RA08771G
      5. Karpavičiene, I.; Jonušis, M.; Leduskrasts, K.; Misiūnaite, I.; Suna, E.; Čikotiene, I. ” Synthesis and photophysical properties of 3,5-diaryl-2-heteroarylthiophenes” Dyes and Pigments 2019, 170, 107646. DOI: 10.1016/j.dyepig.2019.107646
      6. Dumont, E.; Vergalli, J.; Pajovic, J.; Bhamidimarri, S. P.; Morante, K.; Wang, J.; Lubriks, D.; Suna, E.; Stavenger, R. A.; Winterhalter, M.; Refregiers, M.; Pages, J. M. “Mechanistic aspects of maltotriose-conjugate
        translocation to the Gram-negative bacteria cytoplasm” Life Science Alliance 2019, 2, e201800242. DOI: 10.26508/lsa.201800242
      7. Zogota, R.; Kinena, L.; Withers-Martinez, C.; Blackman, M. J.; Bobrovs, R.; Pantelejevs, T.; Kanepe-Lapsa, I.; Ozola, V.; Jaudzems, K.; Suna, E.; Jirgensons, A. “Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D” Eur. J. Med. Chem. 2019, 163, 344-352. DOI: 10.1016/j.ejmech.2018.11.068
      8. Kinens, A.; Balkaitis, S.; Suna, E. “Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts” J. Org. Chem. 2018, 83, 12449–12459. DOI: 10.1021/acs.joc.8b01687
      9. Kinena, L.; Leitis, G.; Kanepe-Lapsa, I.; Bobrovs, R.; Jaudzems. K.; Ozola, V.; Suna, E.; Jirgensons, A. “Azole‐based non‐peptidomimetic plasmepsin inhibitors” Arch. Pharm. Chem. Life Sci. 2018, 351, 1800151. DOI: 10.1002/ardp.201800151
      10. Koleda, O.; Broese, T.; Noetzel, J.; Roemelt, M.; Suna, E.; Francke, R. “Synthesis of Benzoxazoles Using Electrochemically Generated Hypervalent Iodine” J. Org. Chem. 201782, 11669–11681. DOI: 10.1021/acs.joc.7b01686
      11. Kazak, M.; Priede, M.; Shubin, K.; Bartrum, H. E.; Poisson, J.-F.; Suna, E. “Stereodivergent Synthesis of Pseudotabersonine Alkaloids” Org. Lett. 201719, 5356–5359. DOI: 10.1021/acs.orglett.7b02635
      12. Kinens, A.; Sejejs, M.; Kamlet, A. S.; Piotrowski, D. W.; Vedejs, E.; Suna, E. “Development of a Chiral DMAP Catalyst for the Dynamic Kinetic Resolution of Azole Hemiaminals” J. Org. Chem. 201782, 869-886.DOI: 10.1021/acs.joc.6b02955
      13. Priede, M.; Priede, E.; Saame, J.; Leito, I.; Suna, E. “Synthesis of Chiral Phosphazene Bases” Chem. Heterocycl. Comp. 201652, 54-545. DOI: 10.1007/s10593-016-1927-2
      14. Sokolovs, I.; Suna, E. “Para-Selective Cu–catalyzed C–H Aryloxylation of Electron-rich Arenes and Heteroarenes” J. Org. Chem. 201681, 371–379. DOI: 10.1021/acs.joc.5b02728
      15. Berzina, B.; Sokolovs, I.; Suna, E. “Copper-Catalyzed para–Selective C–H Amination of Electron-Rich Arenes” ACS Catalysis 20155, 7008–7014.DOI: 10.1021/acscatal.5b01992
      16. Mutule, I.; Kalnins, T.; Vedejs, E.; Suna, E. “Diazonamide Synthetic Studies. Reactivity of N-Unsubstituted Benzofuro[2,3-b]indolines” Chem. Heterocycl. Comp. 201551, 613-620. PDF
      17. Mutule, I.; Joo, B.; Medne, Z.; Kalnins, T.; Vedejs, E.; Suna, E. “Stereoselective Synthesis of the Diazonamide A Macrocyclic Core” J. Org. Chem. 201580, 3058-3066. DOI: 10.1021/jo502941
      18. Kinens, A.; Kalnins, T.; Suna, E. “Synthesis of 9-Phenylacridines via Ortho-Lithiation–Cyclization Sequence” Chem. Heterocycl. Comp. 20155, 1501-1505DOI: 10.1007/s10593-014-1616-y
      19. Sokolovs, I.; Lubriks, D.; Suna, E. “Copper-Catalyzed Intermolecular C-H Amination of (Hetero)arenes via Transient Unsymmetrical lambda3-Iodanes”  J. Am. Chem. Soc. 2014136, 6920–6928.  DOI: 10.1021/ja502174d
      20. Priede, M.; Kazak, M.; Kalnins, T.; Shubin, K.; Suna, E.  “Diastereoselective Hydroxymethylation of Cyclic Ntert-Butanesulfinylketimines Using Methoxymethanol  as Formaldehyde Source” J. Org. Chem. 201479, 3715–3724. DOI: 10.1021/jo500506u
      21. Krasikovs, A; Ozola, V.; Dax, S. L.; Suna, E. “Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles” Synthesis 201345, 683-693.  DOI: 10.1055/s-0032-1316849
      22. Suna E.; Shubin K. C–C Cross Coupling via C–H Activation: Intramolecular Reaction of Aryl–H and Hetaryl–H Species. In Metal-Catalyzed Heck-Type Reactions and C-H Couplings, Vol. 3, Science of Synthesis Reference Library; Larhed, M.; Odell, L. R, Eds.; Thieme: Stuttgart, New York, 2012, 928 ppISBN (Americas): 9783131642417
      23. Lubriks, D.; Sokolovs, I.; Suna, E. “Indirect C–H Azidation of Heterocycles via Copper-Catalyzed Regioselective Fragmentation of Unsymmetrical λ3-Iodanes” J. Am. Chem. Soc. 2012134, 15436-15442. DOI: 10.1021/ja305574k
      24. Suna, E. “Transition-Metal-Catalyzed Acetoxylation of Heterocycles: All that Glitters is not Palladium” Chem. Heterocycl. Comp. 201248, 44-48. DOI: 10.1007/s10593-012-0967-5.  Full Text
      25. Lubriks, D.; Sokolovs, I.; Suna, E. “Iodonium Salts Are Key Intermediates in Pd-Catalyzed Acetoxylation of Pyrroles” Org. Lett. 201113, 4324-4327. DOI: 10.1021/ol201665c
      26. Martjuga, M.; Belyakov, S.; Liepinsh, E.; Suna, E. “Asymmetric Synthesis of 1,3-Diamines. II: Diastereoselective Reduction of Atropisomeric Ntert-Butanesulfinylketimines” J. Org. Chem. 201176, 2635-2647. DOI: 10.1021/jo1025767
      27. Martjuga, M.; Shabashov, D.; Belyakov, S.; Liepinsh, E.; Suna, E. “Asymmetric Synthesis of 1,3-Diamines by Diastereoselective Reduction of Enantiopure Ntert-Butanesulfinylketimines: Unusual Directing Effects of the ortho-Substituent” J. Org. Chem. 2010, 75, 2375-2368. DOI: 10.1021/jo100173f
      1. Mutule, I.; Suna, E.; Olofsson, K.; Pelcman, B. “Catalytic Direct Acetoxylation of Indoles” J. Org. Chem. 200974, 7195-7198. DOI: 10.1021/jo901321b
      2. Katkevičs M.; Kontijevskis A.; Mutule I.; Sūna E. “Microwave Promoted Automated Synthesis of Coumarin Library” Chem. Heterocycl. Comp. 2007, 151-159. DOI: 10.1007/s10593-007-0025-x
      3. Suna E.; Mutule I. Microwave-assisted Heterocyclic Chemistry. In Microwave Methods in Organic Synthesis; Larhed, M.; Olofsson, K., Eds.; Topics in Current Chemistry; Springer: Berlin, 2006; Vol. 266, pp 49-101. DOI: 10.1007/128_058
      4. Mutule, I.; Suna E. “Arylzinc species by microwave assisted Grignard formation – transmetallation sequence: application in the Negishi coupling” Tetrahedron 200561, 11168-11176. DOI: 10.1016/j.tet.2005.09.022
      5. Mutule, I.; Suna E. “A convenient microwave assisted arylzinc generation-Negishi coupling protocol” Tetrahedron Lett. 200445, 3909-3912. DOI: 10.1016/j.tetlet.2004.03.118
      6. Pottorf, R. S.; Chadha, N. K.; Katkevics, M., Ozola, V., Suna, E.; Ghane, H.; Regberg, T.; Player M. R. “Parallel synthesis of benzoxazoles via microwave-assisted dielectric heating” Tetrahedron Lett. 200344, 175-178. DOI: 10.1016/S0040-4039(02)02495-4
      7. Suna, E. “Resolution of 1-Aryl-1,2,3,4-Tetrahydroisoquinolines via Crystallization of O-Acetylmandelic Amides” Synthesis 2003, 251-254. DOI: 10.1055/s-2003-36832
      8. Vedejs, E.; Kruger, A. W.; Lee, N.; Sakata, S. T.; Stec, M.; Suna, E. “Enantioselective Enolate Protonation with Chiral Anilines: Scope, Structural Requirements, and Mechanistic Implications” J. Am. Chem. Soc. 2000122, 4602-4607. DOI: 10.1021/ja994437m
      9. Suna, E.; Trapencieris, P. “Synthesis of Racemic 1,2,3,4-Tetrahydroisoquinolines and Their Resolution” Chem. Heterocycl. Comp. 2000, 348-361. DOI: 10.1007/BF02256866
      10. Vedejs, E.; Kruger, A.W.; Suna, E. “Enantioselective Enolate Protonation: Matching Chiral Aniline and Substrate Acidity” J. Org. Chem. 199964, 7863-7870. DOI: 10.1021/jo990897m
      11. Vedejs, E.; Trapencieris, P.; Suna, E. “Substituted Isoquinolines by Noyori Transfer Hydrogenation; Enantioselective Synthesis of Chiral Diamines Containing an Aniline Subunit” J. Org. Chem. 199964, 6724-6729. DOI: 10.1021/jo990594s

Patents

      1. Schofield, C.; Brem, J.; Panuwawala, T.; Farley, A.; Suna, E. 2-Carboxyl-indole inhibitors of metallo-beta-lactamases. WO2022/248887 A1, 1 December, 2022.
      2. Suna, E.; Kalnins, T.; Kazak, M.; Vitkovska, V.; Narvaiss, N.; Zelencova, D.; Jaudzems, K. Structurally simplified diazonamide analogs as antimitotic agents. WO2021/130515 A1, 1 July, 2021.
      3. Jirgensons, A.; Kovada, V.; Bobrovs, R.; Suna, E.; Jaudzems, K.; Rasina, D.; Zogota, R. Macrocyclic amides acting as plasmepsin inhbitors for the treatment of malaria. WO2021/123883 A1, 24 June, 2021.
      1. Pelcman, B.; Suna, E.; Stafford, W.; Priede, M. Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer. WO 2018/146472 A1, 16 Aug, 2018
      2. Pelcman, B.; Suna, E.; Stafford, W.; Priede, M. Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer. WO 2018/146469 A1, 16 Aug, 2018
      3. Kinena, L.; Ozola, V.; Suna, E.; Leitis, G.; Jirgensons, A.; Jaudzems, K.; Kanepe-Lapsa, I.; Domracheva, I. 2. Substituted aminoalkylazoles as malarial aspartic protease inhibitors. WO 2017/069601 A1, 27 Apr, 2017
      4. Dax, S. L.; Mencel, J. J.; Ozola, V.; Suna, E.; Shubin, K. Preparation of pyrimido[5,4-d]pyrimidine derivatives as novel breathing control modulating compounds for preventing and/or treating respiratory diseases WO 2017/003822 A1, 5 Jan, 2017
      5. Berzina, B.; Mutule, I.; Suna, E. Hydridopalladium(II) Halides as Preformed Catalysts for Suzuki-Miyaura Cross-Coupling Reactions. WO 2015/063543 A1, 7 May, 2015
      6. Dax, S. L.; Mencel, J. J.; Ozola, V.; Shubin, K.; Martjuga, M.; Suna, E. Novel Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/151462 A1, 25 September, 2014
      7. Mannion, J. C.; Dax, S. L.; Golder, F. J.; Macintyre, D. E.; McLeod, J.; Ozola, V.; Suna, E.; Shubin, K.; Mencel, J. J.; Peng, S. X. Novel Orally Bioavailable Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/078575 A2, 22 May, 2014
      8. Dax, S.L.; Ozola, V.; Krasikovs, A.; Suna, E. Novel Methods for Preparation of (+)-1-ethyl-4-[2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone and Salts Thereof. US 2013/109854  A1, 5 May, 2013
      9. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. Imidazo(4,5-b)pyridine-6-carboxamides as anti-inflammatory agents. WO 2012/076674 A1, 14 June, 2012
      10. Priepke, H.; Kuelzer, R.; Mack, J.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. 2-Aminobenz imidazole derivatives useful in the treatment of inflammation WO 2012/076672 A1, 14 June, 2012
      11. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna, E. 2-(Arylamino)-3H-imidazo-[4,5-b]-pyridine-6-carboxamide derivatives and their use as MPGES-1 inhibitors. WO 2012/022792 A1, 23 February, 2012
      12. Nilsson, P.; Pelcman, B.; Katkevics, M.; Suna, E.; Popovs, I. Bis aromatic compounds for use as LTC4 synthase inhibitors. WO 2010/103283 A1, 16 September, 2010
      13. Pfau, R.; Arndt, K.; Doods, H.; Klinder, K.; Kuelzer, R.; Lubriks, D.; Mack, J.; Pelcman, B.; Priepke, H.; Rönn, R.; Stenkamp, D.; Suna, E. 3H-Imidazo-[4,5-c]-pyridine-6-carboxamides as anti-inflammatory agents. WO 2010/100249 A1, 10 September, 2010
      1. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Andrianov, V. Disulfonamides useful in the treatment of inflammation. WO 2008/129276 A1, 30 October, 2008
      2. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Krasikovs, A. Disulfonamides useful in the treatment of inflammation. WO 2008/129288 A2, 30 October, 2008
      3. Pelcman, B.; Olofsson, K.; Kalvins, I.; Suna, E.; Ozola, V.; Schaal, W. Benzoxazoles useful in the treatment of inflammation. WO 2008/071944, 19 June, 2008
      4. Pelcman B.; Olofsson K.; Katkevics M.; Ozola V.; Suna E.; Kalvins I.; Arsenjans P. Indoles useful in the treatment of inflammation. WO 2008/009924 A2, 24 January, 2008
      5. Pelcman, B; Olofsson, K.; Habarova, O.; Kalvins, I.; Suna, E.; Trapencieris, P.; Andrianov, V. Naphthalene-disulfonamides useful for the treatment of inflammation. WO 2007/042817 A1, 19 April 2007
      6. Pelcman, B; Olofsson, K.; Schaal, W.; Kalvins, I.; Katkevics, M.; Ozola, V.; Suna E. Benzoxazoles useful in the treatment of inflammation. WO 2007/042816 A1, 19 April 2007
      7. Pelcman, B; Olofsson, K.; Arsenjans, P.; Ozola, V.; Suna E.; Kalvins, I. Thienopyrroles useful in the treatment of inflammation. WO 2006/077412 A1, 27 July 2006
      8. Pelcman, B; Olofsson, K.; Arsenjans, P.; Kalvins, I.; Suna E.;. Katkevics, M.; Madre, M.; Ozola, V. Pyrrolopyridines useful in the treatment of inflammation. WO 2006/077401 A1, 27 July 2006
      9. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077367 A1, 27 July 2006
      10. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077366 A1, 27 July 2006
      11. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077365 A1, 27 July 2006
      12. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P. Indoles useful in the treatment of inflammation. WO 2006/077364 A1, 27 July 2006
      13. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123675 A1, 29 Dec 2005
      14. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123674 A1, 29 Dec 2005
      15. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/123673 A1, 29 Dec 2005
      16. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/005415 A1, 20 Jan 2005