Dr. Ilga Mutule

Dr. Ilga Mutule

Former PhD student, Project Leader

Curriculum Vitae

Education

PhD in chemistry, Riga Technical University, 2006
Thesis: “Application of Microwaves in Organic Synthesis”
Supervisor: Prof. E. Suna

Diploma, Chemistry, Riga Technical University, 1997

Experience

Latvian Institute of Organic Synthesis
Research Scientist, 2005-present
Research Assistant, 1997-1998 and 2000-2005
Laboratory Assistant, 1996-1997

Uppsala University
Laboratory Assistant, Department of Pharmaceutical Pharmacology, 1998-2000

University of Michigan, USA
Research scientist, 2011 (4 months)

Publications

  1. Jaunsleine, K.; Supe, L.; Spura, J.; van Beek, S.; Sandström, A.; Olsen, J.; Halleskog, C.; Bengtsson, T.; Mutule, I.; Pelcman, B. Development of Novel Β2-Adrenergic Receptor Agonists for the Stimulation of Glucose Uptake – The Importance of Chirality and Ring Size of Cyclic Amines. Bioorganic & Medicinal Chemistry Letters 2024, 97, 129562. DOI: 10.1016/j.bmcl.2023.129562.
  2. Mutule, I.; Kalnins, T.; Vedejs, E.; Suna, E. “Diazonamide Synthetic Studies. Reactivity of N-Unsubstituted Benzofuro[2,3-b]indolines” Chem. Heterocycl. Comp. 2015, 51, 613-620. PDF
  3. Mutule, I.; Joo, B.; Medne, Z.; Kalnins, T.; Vedejs, E.; Suna, E. “Stereoselective Synthesis of the Diazonamide A Macrocyclic Core” J. Org. Chem. 2015, 80, 3058-3066. DOI: 10.1021/jo502941
  4. Mutule, I.; Suna, E.; Olofsson, K.; Pelcman, B. “Catalytic Direct Acetoxylation of Indoles” J. Org. Chem.2009, 74, 7195-7198. DOI: 10.1021/jo901321b
  5. Katkevičs M.; Kontijevskis A.; Mutule I.; Sūna E. “Microwave Promoted Automated Synthesis of Coumarin Library” Chem. Heterocycl. Comp. 2007, 151-159. DOI: 10.1007/s10593-007-0025-x
  6. Schioth, H. B.; Muceniece, R.; Mutule, I.; Wikberg, J. E .S. “New Melanokortin 1 Receptor Binding Motif Based on the C-terminal Sequence of α-Melanocyte-stimulating Hormone” Basic& Clinical Pharmacology & Toxicology 2006, 99, 287-293. DOI: 10.1111/j.1742-7843.2006.pto_459.x
  7. Suna E.; Mutule I. Microwave-assisted Heterocyclic Chemistry. In Microwave Methods in Organic Synthesis; Larhed, M.; Olofsson, K., Eds.; Topics in Current Chemistry; Springer: Berlin, 2006; Vol. 266, pp 49-101. DOI: 10.1007/128_058
  8. Mutule, I.; Suna E. “Arylzinc species by microwave assisted Grignard formation – transmetallation sequence: application in the Negishi coupling” Tetrahedron 2005, 61, 11168-11176. DOI: 10.1016/j.tet.2005.09.022
  9. Mutule, I.; Suna E. “A convenient microwave assisted arylzinc generation-Negishi coupling protocol”Tetrahedron Lett. 2004, 45, 3909-3912. DOI: 10.1016/j.tetlet.2004.03.118

Patents

  1. Berzina, B.; Mutule, I.; Suna, E. Hydridopalladium(II) Halides as Preformed Catalysts for Suzuki-Miyaura Cross-Coupling Reactions. WO2015/063543 A1, 7 May, 2015