Sulfur stereochemistry

Chiral-at-sulfur compounds are increasingly important tools in modern organic synthesis, offering access to three-dimensional molecular structures that are difficult to achieve using carbon-centered chirality alone. Key examples include Ellman’s chiral sulfinamides, which are widely used as versatile auxiliaries and building blocks, as well as aza-analogues of sulfones such as sulfondiimines and sulfonimidamides. These sulfur-based motifs combine stereogenic sulfur with tunable electronic properties and broad opportunities for chemical modification, making them valuable in asymmetric synthesis and medicinal chemistry.

Our research group focuses on the development of new synthetic methods using Ellman’s N-tert-butanesulfinyl chiral auxiliary and on the stereoselective synthesis of chiral-at-sulfur molecules.