Every fourth new drug discovered and launched during the last 30 years mimics natural products. Therefore chemists must be able to construct complex molecules. Total synthesis of complex natural products is a superior way of training students in synthetic organic chemistry.
Diazonamide A
(+)-Pseudotabersonine
Funding
ESF grant (1DP/1.1.1.2.0/13/APIA/VIAA/006)
Publications
20. Stereodivergent Synthesis of Pseudotabersonine Alkaloids
Kazak, M.; Priede, M.; Shubin, K.; Bartrum, H. E.; Poisson, J.-F.; Suna, E. Org. Lett. 2017, 19, 5356–5359.
15. Diazonamide Synthetic Studies. Reactivity of N-Unsubstituted Benzofuro[2,3-b]indolines
Mutule, I.; Kalnins, T.; Vedejs, E.; Suna, E. Chem. Heterocycl. Comp. 2015, 51, 613-620.
14. Stereoselective Synthesis of the Diazonamide A Macrocyclic Core
Mutule, I.; Joo, B.; Medne, Z.; Kalnins, T.; Vedejs, E.; Suna, E. J. Org. Chem. 2015, 80, 3058-3066.
DOI: 10.1021/jo502941