{"id":2804,"date":"2018-04-28T21:42:55","date_gmt":"2018-04-28T19:42:55","guid":{"rendered":"https:\/\/ospt.osi.lv\/?page_id=2804"},"modified":"2018-11-02T23:07:10","modified_gmt":"2018-11-02T21:07:10","slug":"drug-discovery","status":"publish","type":"page","link":"https:\/\/ospt.osi.lv\/drug-discovery\/","title":{"rendered":"Drug discovery projects on a contract research base"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]<\/p>\n

Development of mPGES-1 inhibitors for treatment of inflammatory pain<\/h2>\n

Our laboratory has been involved in a long-term collaboration project with Swedish company\u00a0BIOLIPOX<\/a>aimed at the development of a medication for treatment of inflammatory pain, such as from rheumatoid arthritis.
\nThe goal of the project was design of selective inhibitor of membrane-bound prostaglandin (PG) E synthase (mPGES-1), an enzyme necessary for the production of Prostaglandin E2 (PGE2).
\nIn 2010, a candidate drug for further clinical development has been selected (OREXO press-release<\/a>).<\/p>\n

[\/vc_column_text][vc_toggle title=”Patents”]<\/p>\n

    \n
  1. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; R\u00f6nn, R.; Lubriks, D.; Suna E.Imidazo(4,5-b)pyridine-6-carboxamides as anti-inflammatory agents. WO2012\/076674 A1, 14 June, 2012<\/li>\n
  2. Priepke, H.; Kuelzer, R.; Mack, J.; Pfau, R.; Stenkamp, D.; Pelcman, B.; R\u00f6nn, R.; Lubriks, D.; Suna E.2-Aminobenz imidazole derivatives useful in the treatment of inflammation WO2012\/076672 A1, 14 June, 2012<\/li>\n
  3. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; R\u00f6nn, R.; Lubriks, D.; Suna E.2-(Arylamino)-3H-imidazo-[4,5-b]-pyridine-6-carboxamide derivatives and their use as MPGES-1 inhibitors. WO2012\/022792 A1, 23 February, 2012<\/li>\n
  4. Pfau, R.; Arndt, K.; Doods, H.; Klinder, K.; Kuelzer, R.; Lubriks, D.; Mack, J.; Pelcman, B.; Priepke, H.; R\u00f6nn, R.; Stenkamp, D.; Suna E. 3H-Imidazo-[4,5-c]-pyridine-6-carboxamides as anti-inflammatory agents. WO2010\/100249 A1, 10 September, 2010<\/li>\n
  5. Pelcman, B.; Olofsson, K.; Suna E.; Kalvins, I.; Ozola, V.; Andrianov, V. Disulfonamides useful in the treatment of inflammation. WO 2008\/129276 A1, 30 October, 2008<\/li>\n
  6. Pelcman, B.; Olofsson, K.; Suna E.; Kalvins, I.; Ozola, V.; Krasikovs, A. Disulfonamides useful in the treatment of inflammation. WO 2008\/129288 A2, 30 October, 2008<\/li>\n
  7. Pelcman, B.; Olofsson, K.; Kalvins, I.; Suna E.; Ozola, V.; Schaal, W. Benzoxazoles useful in the treatment of inflammation. WO 2008\/071944, 19 June, 2008<\/li>\n
  8. Pelcman B.; Olofsson K.; Katkevics M.; Ozola V.; Suna E.; Kalvins I.; Arsenjans P. Indoles useful in the treatment of inflammation. WO 2008\/009924 A2, 24 January, 2008<\/li>\n
  9. Pelcman, B; Olofsson, K.; Habarova, O.; Kalvins, I.; Suna E.; Trapencieris, P.; Andrianov, V. Naphthalene-disulfonamides useful for the treatment of inflammation. WO 2007\/042817 A1, 19 April 2007<\/li>\n
  10. Pelcman, B; Olofsson, K.; Schaal, W.; Kalvins, I.; Katkevics, M.; Ozola, V.; Suna E. Benzoxazoles useful in the treatment of inflammation. WO 2007\/042816 A1, 19 April 2007<\/li>\n
  11. Pelcman, B; Olofsson, K.; Arsenjans, P.; Ozola, V.; Suna E.; Kalvins, I. Thienopyrroles useful in the treatment of inflammation. WO 2006\/077412 A1, 27 July 2006<\/li>\n
  12. Pelcman, B; Olofsson, K.; Arsenjans, P.; Kalvins, I.; Suna E.;. Katkevics, M.; Madre, M.; Ozola, V.Pyrrolopyridines useful in the treatment of inflammation. WO 2006\/077401 A1, 27 July 2006<\/li>\n
  13. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006\/077367 A1, 27 July 2006<\/li>\n
  14. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006\/077366 A1, 27 July 2006<\/li>\n
  15. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006\/077365 A1, 27 July 2006<\/li>\n
  16. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P. Indoles useful in the treatment of inflammation. WO 2006\/077364 A1, 27 July 2006<\/li>\n
  17. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005\/123675 A1, 29 Dec 2005<\/li>\n
  18. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005\/123674 A1, 29 Dec 2005<\/li>\n
  19. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005\/123673 A1, 29 Dec 2005<\/li>\n
  20. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005\/005415 A1, 20 Jan 2005<\/li>\n<\/ol>\n

    [\/vc_toggle][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n

    Development of drugs for treatment of breathing-control disorders<\/h2>\n

    In collaboration with\u00a0Galleon Pharma, Inc.<\/a>\u00a0(USA) our laboratory has been working on the development of drugs for\u00a0treatment of breathing-control disorders such as sleep apnea and post surgical respiratory insufficiency.<\/p>\n

    [\/vc_column_text][vc_toggle title=”Patents”]<\/p>\n

      \n
    1. Dax, S. L.; Mencel, J. J.; Ozola, V.; Suna, E.; Shubin, K. Preparation of pyrimido[5,4-d]pyrimidine derivatives as novel breathing control modulating compounds for preventing and\/or treating respiratory diseases WWO 2017\/003822 A1, 5 Jan, 2017<\/li>\n
    2. Mannion, J. C.; Dax, S. L.; Woodward, R.; Ozola, V. Compositions and methods for treating breathing control disorders or diseases. WO 2012\/166909 A1, 6 Dec, 2012<\/li>\n
    3. Mannion, J. C.; Dax, S. L.; Golder, F. J.; Macintyre, D. E.; McLeod, J.; Ozola, V.; Suna, E.; Shubin, K.; Mencel, J. J.; Peng, S. X. Novel Orally Bioavailable Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014\/078575 A2, 22 May, 2014<\/li>\n
    4. Dax, S. L.; Mencel, J. J.; Ozola, V.; Shubin, K.; Martjuga, M.; Suna, E. Novel Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014\/151462 A1, 25 September, 2014<\/li>\n<\/ol>\n

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      [vc_row][vc_column][vc_column_text] Development of mPGES-1 inhibitors for treatment of inflammatory pain Our laboratory has been involved in a long-term collaboration project with Swedish company\u00a0BIOLIPOXaimed at the development of a medication for treatment of inflammatory pain, such as from rheumatoid arthritis. The goal of the project was design of selective inhibitor of membrane-bound prostaglandin (PG) E synthase […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/pages\/2804"}],"collection":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/comments?post=2804"}],"version-history":[{"count":0,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/pages\/2804\/revisions"}],"wp:attachment":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media?parent=2804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}