{"id":2655,"date":"2013-02-21T14:49:40","date_gmt":"2013-02-21T12:49:40","guid":{"rendered":"https:\/\/ospt.osi.lv\/?p=2655"},"modified":"2022-01-11T12:13:12","modified_gmt":"2022-01-11T10:13:12","slug":"iodoacetic-acid-is-an-efficient-reagent-for-the-synthesis-of-amino-acid-derived-2-aminobenzimidazoles","status":"publish","type":"post","link":"https:\/\/ospt.osi.lv\/iodoacetic-acid-is-an-efficient-reagent-for-the-synthesis-of-amino-acid-derived-2-aminobenzimidazoles\/","title":{"rendered":"10. Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles"},"content":{"rendered":"<p>Krasikovs, A; Ozola, V.; Dax, S. L.; Suna, E. <cite>Synthesis<\/cite> <strong>2013<\/strong>, <em>45<\/em>, 683-693.<\/p>\n<p>DOI: <a href=\"http:\/\/dx.doi.org\/10.1055\/s-0032-1316849\" target=\"_blank\" rel=\"noopener\">10.1055\/s-0032-1316849<\/a><\/p>\n<p><!--more--><\/p>\n<p>Abstract<\/p>\n<p>Chiral, nonracemic, N-unprotected amino acids were converted into the corresponding <span class=\"i\">N<\/span>-benzimidazol-2-yl derivatives by a sequential procedure involving initial formation of isothiocyanates, their reaction with arene-1,2-diamines, and cyclization\u2013desulfurization\u00ad of the intermediate thioureas with iodoacetic acid. The simplified workup and the lack of volatile or toxic byproducts in the key desulfurization step renders iodoacetic acid a superior reagent to the usual reagent, iodomethane.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Krasikovs, A; Ozola, V.; Dax, S. L.; Suna, E. Synthesis 2013, 45, 683-693. DOI: 10.1055\/s-0032-1316849<\/p>\n","protected":false},"author":1,"featured_media":2656,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[16],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/2655"}],"collection":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/comments?post=2655"}],"version-history":[{"count":1,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/2655\/revisions"}],"predecessor-version":[{"id":3983,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/2655\/revisions\/3983"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media\/2656"}],"wp:attachment":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media?parent=2655"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/categories?post=2655"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/tags?post=2655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}