{"id":3143,"date":"2018-10-22T12:38:47","date_gmt":"2018-10-22T10:38:47","guid":{"rendered":"https:\/\/ospt.osi.lv\/?p=3143"},"modified":"2022-01-11T12:15:10","modified_gmt":"2022-01-11T10:15:10","slug":"preparative-scale-synthesis-of-vedejs-chiral-dmap-catalysts","status":"publish","type":"post","link":"https:\/\/ospt.osi.lv\/preparative-scale-synthesis-of-vedejs-chiral-dmap-catalysts\/","title":{"rendered":"22. Preparative-Scale Synthesis of Vedejs Chiral DMAP Catalysts"},"content":{"rendered":"<p>Kinens, A.; Balkaitis, S.; Suna, E. <em>J. Org. Chem.<\/em> <strong>2018<\/strong>, <em>83<\/em>, 12449\u201312459.<\/p>\n<p>DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.8b01687\" target=\"_blank\" rel=\"noopener\">10.1021\/acs.joc.8b01687<\/a><\/p>\n<p><!--more--><\/p>\n<h4>Abstract<\/h4>\n<p>A scalable synthesis of chiral Vedejs-type DMAP catalysts is reported. The key step of the synthesis is amination of the enantiomerically pure 4-chloropyridine derivative using well-defined ZnCl<sub>2<\/sub>(amine)<sub>2<\/sub> complexes. A series of Zn(II)\u2013amine complexes have been synthesized to explore the scope of the ZnCl<sub>2<\/sub>-mediated amination of 4-halopyridines. Mechanistic studies support a Zn(II)-facilitated nucleophilic aromatic substitution as a plausible mechanism for the chlorine-to-amine exchange.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kinens, A.; Balkaitis, S.; Suna, E. J. Org. Chem. 2018, 83, 12449\u201312459. DOI: 10.1021\/acs.joc.8b01687<\/p>\n","protected":false},"author":1,"featured_media":3146,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[45,16],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/3143"}],"collection":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/comments?post=3143"}],"version-history":[{"count":1,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/3143\/revisions"}],"predecessor-version":[{"id":3995,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/3143\/revisions\/3995"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media\/3146"}],"wp:attachment":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media?parent=3143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/categories?post=3143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/tags?post=3143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}