{"id":3749,"date":"2020-06-12T22:33:27","date_gmt":"2020-06-12T20:33:27","guid":{"rendered":"https:\/\/ospt.osi.lv\/?p=3749"},"modified":"2022-01-11T12:15:48","modified_gmt":"2022-01-11T10:15:48","slug":"tetrahydroisoquinoline-based-non-peptidomimetic-plasmepsin-inhibitors","status":"publish","type":"post","link":"https:\/\/ospt.osi.lv\/tetrahydroisoquinoline-based-non-peptidomimetic-plasmepsin-inhibitors\/","title":{"rendered":"28. Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]Kinena, L.; Ozola, V. <em>Chem. Heterocycl. Comp. <\/em><strong>2020<\/strong>, <em>56<\/em>, 60\u201366.<\/p>\n<p>DOI: <a title=\"Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors\" href=\"https:\/\/doi.org\/10.1007\/s10593-020-02623-6\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">10.1007\/s10593-020-02623-6<\/a><\/p>\n<p><!--more--><\/p>\n<h4>Abstract<\/h4>\n<p style=\"text-align: justify;\">A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet\u2013Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory activity against plasmepsins I and II.<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text]Kinena, L.; Ozola, V. Chem. Heterocycl. Comp. 2020, 56, 60\u201366. DOI: 10.1007\/s10593-020-02623-6<\/p>\n","protected":false},"author":1,"featured_media":3761,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[38,16],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/3749"}],"collection":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/comments?post=3749"}],"version-history":[{"count":1,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/3749\/revisions"}],"predecessor-version":[{"id":4001,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/3749\/revisions\/4001"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media\/3761"}],"wp:attachment":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media?parent=3749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/categories?post=3749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/tags?post=3749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}