{"id":3753,"date":"2020-06-13T13:37:16","date_gmt":"2020-06-13T11:37:16","guid":{"rendered":"https:\/\/ospt.osi.lv\/?p=3753"},"modified":"2024-01-05T19:17:08","modified_gmt":"2024-01-05T17:17:08","slug":"aliphatic-chain-containing-macrocycles-as-diazonamide-a-analogs","status":"publish","type":"post","link":"https:\/\/ospt.osi.lv\/aliphatic-chain-containing-macrocycles-as-diazonamide-a-analogs\/","title":{"rendered":"30. Aliphatic chain-containing macrocycles as diazonamide A analogs"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]Vitkovska, V.; Zogota, R.; Kalnins, T.; Zelencova, D.; Suna, E. <em>Chem. Heterocycl. Comp. <\/em><strong>2020<\/strong>, <em>56<\/em>, 586\u2013602.<\/p>\n<p>DOI: <a title=\"Aliphatic chain-containing macrocycles as diazonamide A analogs\" href=\"https:\/\/doi.org\/10.1007\/s10593-020-02704-6\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">10.1007\/s10593-020-02704-6<\/a><\/p>\n<p><!--more--><\/p>\n<h4>Abstract<\/h4>\n<p style=\"text-align: justify;\">Aliphatic alkyl chain-containing 12\u201314-membered macrocycles have been designed as structural analogs of antimitotic natural product diazonamide A. Macrocycles were synthesized from 5-bromooxazole in 7 to 9 linear steps using Ru-catalyzed ring-closing metathesis as the key transformation. Heat effect of binding to \u03b1,\u03b2-tubulin tetramer (T4-RB3 complex) has been measured for the synthesized macrocycles by isothermal titration calorimetry method.<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text]Vitkovska, V.; Zogota, R.; Kalnins, T.; Zelencova, D.; Suna, E. Chem. Heterocycl. Comp. 2020, 56, 586\u2013602. DOI: 10.1007\/s10593-020-02704-6<\/p>\n","protected":false},"author":1,"featured_media":3759,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[39,16],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/3753"}],"collection":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/comments?post=3753"}],"version-history":[{"count":1,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/3753\/revisions"}],"predecessor-version":[{"id":4003,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/3753\/revisions\/4003"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media\/3759"}],"wp:attachment":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media?parent=3753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/categories?post=3753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/tags?post=3753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}