{"id":4101,"date":"2022-12-27T10:42:01","date_gmt":"2022-12-27T08:42:01","guid":{"rendered":"https:\/\/ospt.osi.lv\/?p=4101"},"modified":"2023-01-11T08:42:15","modified_gmt":"2023-01-11T06:42:15","slug":"synthesis-antibacterial-and-antiribosomal-activity-of-the-3c-aminoalkyl-modification-in-the-ribofuranosyl-ring-of-apralogs","status":"publish","type":"post","link":"https:\/\/ospt.osi.lv\/synthesis-antibacterial-and-antiribosomal-activity-of-the-3c-aminoalkyl-modification-in-the-ribofuranosyl-ring-of-apralogs\/","title":{"rendered":"41. Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]Lubriks, D.; Haldimann, K.; Hobbie, S. N.; Vasella A.; Suna E.; Crich D.; <em>Antibiotics<\/em> <strong>2023<\/strong>,<em> 12, <\/em>25\u201339. DOI: <a title=\"Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)\" href=\"https:\/\/doi.org\/10.3390\/antibiotics12010025\" target=\"_blank\" rel=\"nofollow noopener\">10.3390\/antibiotics12010025<\/a><\/p>\n<p><!--more--><\/p>\n<h4>Abstract<\/h4>\n<p style=\"text-align: justify;\">The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-<span class=\"html-italic\">O<\/span>-(5-amino-3-<span class=\"html-italic\">C<\/span>-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosomes and that of MRSA and various wild-type Gram negative pathogens. The new compounds retain activity in the presence of the aminoglycoside phosphoryltransferase aminoglycoside modifying enzymes that act on the primary hydroxy group of typical 4,5-(2-deoxystreptamine)-type aminoglycoside and related apramycin derivatives. Unexpectedly, the two anomers have comparable activity both for the inhibition of bacterial ribosomes and of the various bacterial strains tested.<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text]Lubriks, D.; Haldimann, K.; Hobbie, S. N.; Vasella A.; Suna E.; Crich D.; Antibiotics 2023, 12, 25\u201339. DOI: 10.3390\/antibiotics12010025<\/p>\n","protected":false},"author":1,"featured_media":4103,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[40,16],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/4101"}],"collection":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/comments?post=4101"}],"version-history":[{"count":3,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/4101\/revisions"}],"predecessor-version":[{"id":4106,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/posts\/4101\/revisions\/4106"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media\/4103"}],"wp:attachment":[{"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/media?parent=4101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/categories?post=4101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ospt.osi.lv\/wp-json\/wp\/v2\/tags?post=4101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}