Dr. Vita Ozola

Dr. Vita Ozola

Project Leader

Curriculum Vitae

Education

PhD in chemistry, Latvian Institute of Organic Synthesis, 1998
Thesis: “Synthesis and Properties of C-8 Substituted 2,6-Diaminopurine and Alkylxanthine Nucleosides.”
Supervisor: Dr. chem. J. Maurins
Diploma, Chemical Technology, Riga Technical University, 1991

Experience

Latvian Institute of Organic Synthesis
Principal Scientist, 2006-present
Research Scientist, 1998-2006
Research Associate, 1991-1998
Research Assistant, 1989-1991

Riga Technical University
Laboratory Assistant, 1987-1989

Lund University, Sweden
Postgraduate student, 1993 (6 months), 1994 (4 months)
Advisor: Prof. S. Gronowitz

King’s College London, UK
Visiting researcher, 1996 (3 months)
Advisor: Prof. C. B. Reese

University of Würzburg, Germany
Postdoctoral student, 1998 (3 months)
Advisor: Prof. C. E. Müller

University of Bonn, Germany
Postdoctoral student, 1998 (3 months), 1999 (4 months)
Advisor: Prof. C. E. Müller

Honors and Awards

ACADEMIA EUROPAEA Prize for Young Scientists from Estonia, Latvia, Lithuania, year 1996

Publications

  1. Kinena, L.; Ozola, V. “Tetrahydroisoquinoline-Based Non-Peptidomimetic Plasmepsin Inhibitors” Chem. Heterocycl. Comp. 2020, 56, 60–66. DOI: 10.1007/s10593-020-02623-6
  2. Zogota, R.; Kinena, L.; Withers-Martinez, C.; Blackman, M., J.; Bobrovs, R.; Pantelejevs, T.; Kanepe-Lapsa, I.; Ozola, V.; Jaudzems, K.; Suna, E.; Jirgensons, A. “Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D” Eur. J. Med. Chem. 2019, 163, 344-352. DOI: 10.1016/j.ejmech.2018.11.068
  3. Kinena, L.; Leitis, G.; Kanepe-Lapsa, I.; Bobrovs, R.; Jaudzems. K.; Ozola, V.; Suna, E.; Jirgensons, A. “Azole‐based non‐peptidomimetic plasmepsin inhibitors” Arch. Pharm. Chem. Life Sci. 2018, 351, 1800151. DOI: 10.1002/ardp.201800151
  4. Krasikovs, A; Ozola, V. “Synthesis of 1-Methoxy-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one” Chem. Heterocycl. Comp. 2013, 49, 496-499. DOI: 10.1007/s10593-013-1274-5
  5. Krasikovs, A; Ozola, V.; Dax, S. L.; Suna, E. “Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles” Synthesis 2013, 45, 683-693.  DOI: 10.1055/s-0032-1316849
  6. Pottorf, R. S.; Chadha, N. K.; Katkevics, M.; Ozola, V.; Suna, E.; Ghane, H.; Regberg, T.; Player M. R. “Parallel synthesis of benzoxazoles via microwave-assisted dielectric heating” Tetrahedron Lett. 2003, 44, 175-178. DOI: 10.1016/S0040-4039(02)02495-4
  7. Ozola, V.; Thorand, M.; Dieckmann, M.; Schumacher, B.; Jacobson, K.A.; Müller, C.E. “2-Phenylimidazo[2,1-i]purin-5-ones: Structure-Activity Relationships and Characterization of Potent and Selective Inverse Agonists at Human A3 Adenosine Receptors.” Bioorg. Med. Chem. 2003, 11, 353-361. DOI: 10.1016/S0968-0896(02)00456-X
  8. Müller, C.E.; Dieckmann, M.; Thorand, M.; Ozola, V. “[3H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([3H]PSB-11), a Novel High-Affinity Antagonist Radioligand for Human A3Adenosine Receptors.” Bioorg. Med. Chem. Lett. 2002, 12, 501-503. DOI: 10.1016/S0960-894X(01)00785-5
  9. Ozola V.; Maurinsh Y.; Lidaka M. “Synthesis of Derivatives of 3-Methylxanthine and 1-Methyl-3-Isobutylxanthine 7-β-D-Ribofuranosides. Nucleosides Nucleotides 1998, 17(9-11), 1983-1986. DOI: 10.1080/07328319808004737
  10. Ozola V.; Reese C.B.; Song Q. “Use of ammonium aryl H-phosphonates in the preparation of nucleoside H-phosphonate building blocks.” Tetrahedron Lett. 1996, 37(47), 8621-8624. DOI: 10.1016/0040-4039(96)01993-4
  11. Ozola V.; Persson T.; Gronowitz S.; Hornfeldt A.-B. “On the synthesis of 8-heteroaryl-substituted 9-(beta-D-ribofuranosyl)-2,6-diaminopurines through Pd-catalyzed coupling in the presence of cupric oxide.” J. Heterocycl. Chem. 1995, 32(3), 863-866. DOI: 10.1002/jhet.5570320331
  12. Ozola V.; Ramzaeva N.; Maurinsh Y.; Lidaks M. Synthesis of 8-substituted theophylline beta-D-ribofuranosides. Nucleosides Nucleotides 1993, 12(8), 827-839. DOI: 10.1080/07328319308018553
  13. Ozola V.; Ramzaeva N.; Maurinsh Y.; Lidaks M. Synthesis of 8-substituted 7-(alfa-L-arabinofuranosyl)theophyllines. Nucleosides Nucleotides 1993, 12(5), 479-486. DOI: 10.1080/07328319308021217

Patents

  1. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/005415 A1, 20 Jan 2005
  2. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I. Indoles useful in the treatment of inflammation. WO 2005/123673 A1, 29 Dec 2005
  3. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123674 A1, 29 Dec 2005
  4. Olofsson, K.; Suna E.; Pelcman, B.; Ozola, V.; Katkevics, M.; Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2005/123675 A1, 29 Dec 2005
  5. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P. Indoles useful in the treatment of inflammation. WO 2006/077364 A1, 27 July 2006
  6. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077365 A1, 27 July 2006
  7. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077366 A1, 27 July 2006
  8. Pelcman, B; Olofsson, K.; Katkevics, M.; Ozola, V.; Suna E.;. Kalvins, I.; Trapencieris, P.; Katkevica, D.; Schaal, W. Indoles useful in the treatment of inflammation. WO 2006/077367 A1, 27 July 2006
  9. Pelcman, B; Olofsson, K.; Arsenjans, P.; Kalvins, I.; Suna E.;. Katkevics, M.; Madre, M.; Ozola, V. Pyrrolopyridines useful in the treatment of inflammation. WO 2006/077401 A1, 27 July 2006
  10. Pelcman, B; Olofsson, K.; Arsenjans, P.; Ozola, V.; Suna E.; Kalvins, I. Thienopyrroles useful in the treatment of inflammation. WO 2006/077412 A1, 27 July 2006
  11. Pelcman, B; Olofsson, K.; Schaal, W.; Kalvins, I.; Katkevics, M.; Ozola, V.; Suna E. Benzoxazoles useful in the treatment of inflammation. WO 2007/042816 A1, 19 April 2007
  12. Pelcman B.; Olofsson K.; Katkevics M.; Ozola V.; Suna E.; Kalvins I.; Arsenjans P. Indoles useful in the treatment of inflammation. WO 2008/009924 A2, 24 January, 2008
  13. Pelcman, B.; Olofsson, K.; Kalvins, I.; Suna, E.; Ozola, V.; Schaal, W. Benzoxazoles useful in the treatment of inflammation. WO 2008/071944, 19 June, 2008
  14. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Krasikovs, A. Disulfonamides useful in the treatment of inflammation. WO 2008/129288 A2, 30 October, 2008
  15. Pelcman, B.; Olofsson, K.; Suna, E.; Kalvins, I.; Ozola, V.; Andrianov, V. Disulfonamides useful in the treatment of inflammation. WO 2008/129276 A1, 30 October, 2008
  16. Mannion, J. C.; Dax, S. L.; Woodward, R.; Ozola, V.  Compositions and methods for treating breathing control disorders or diseases. WO 2012/166909 A1, 6 Dec, 2012
  17. Dax, S.L.; Ozola, V.; Krasikovs, A.; Suna, E. Novel Methods for Preparation of (+)-1-ethyl-4-[2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone and Salts Thereof. US2013/109854  A1, 5 May, 2013
  18. Mannion, J. C.; Dax, S. L.; Golder, F. J.; Macintyre, D. E.; McLeod, J.; Ozola, V.; Suna, E.; Shubin, K.; Mencel, J. J.; Peng, S. X. Novel Orally Bioavailable Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/078575 A2, 22 May, 2014
  19. Dax, S. L.; Mencel, J. J.; Ozola, V.; Shubin, K.; Martjuga, M.; Suna, E. Novel Breathing Control Modulating Compounds, and Methods of Using Same. WO 2014/151462 A1, 25 September, 2014
  20. Kinena, L.; Ozola, V.; Suna, E.; Leitis, G.; Jirgensons, A.; Jaudzems, K.; Kanepe-Lapsa, I.; Domracheva, I. 2. Substituted aminoalkylazoles as malarial aspartic protease inhibitors. WO 2017069601 A1, 27 Apr, 2017
  21. Dax, S. L.; Mencel, J. J.; Ozola, V.; Suna, E.; Shubin, K. Preparation of pyrimido[5,4-d]pyrimidine derivatives as novel breathing control modulating compounds for preventing and/or treating respiratory diseases WWO 2017/003822 A1, 5 Jan, 2017