Publications | Edgars Suna Group

64. Electrochemistry of Hypervalent Halogen Compounds

Sokolovs, I.; Suna, E.; Francke, R. Electrochemistry of Hypervalent Halogen Compounds. Acc. Chem. Res. 2026, 59, 11, 1949–1959. https://doi.org/10.1021/acs.accounts.6c00248.

63. Stereospecific SuFEx reactivity of highly enantioenriched sulfondiimidoyl fluorides

Jersovs, G.; Pivars, A. J.; Bariseva, J.; Kovada, V.; Donets, P. A.; Suna, E. Stereospecific SuFEx Reactivity of Highly Enantioenriched Sulfondiimidoyl Fluorides. Org. Chem. Front. 2026, Advance Article. https://doi.org/10.1039/D6QO00230G

62. Through-space cation–π quadrupole–monopole design enables selective suppression of third-order nonlinear optical Kerr effects

Jelisejevs, D.; Bundulis, A.; Sapne, A.; Leduskrasts, K. Through-space cation–π quadrupole–monopole design enables selective suppression of third-order nonlinear optical Kerr effects. J. Mater. Chem. C 2026, Advance Article. https://doi.org/10.1039/D6TC00480F

61. Investigation of structure, optical properties and chemical stability of the KL1421 pyridinium luminophore with high quantum yield

Zabolotnii, V.; Tamuliene, J.; Drava, M. M.; Kirova, T.; Tepliakova, I.; Lukinsone, V.; Kinens, A.; Viter, R. Investigation of Structure, Optical Properties and Chemical Stability of the KL1421 Pyridinium Luminophore with High Quantum Yield. Appl. Mater. Today 2025, 46, 102890. DOI: 10.1016/j.apmt.2025.102890

60. Electrochemical synthesis of cyclic biaryl λ3-bromanes from 2,2’-dibromobiphenyls

Savkins, A.; Sokolovs, I. Electrochemical synthesis of cyclic biaryl λ3-bromanes from 2,2’-dibromobiphenyls. Beilstein J. Org. Chem. 2025, 21, 451–457. DOI: 10.3762/bjoc.21.32

59. Chiral Epoxy-Imine Building Block for Diversity-Oriented Synthesis of Peptidomimetic Aspartic Protease Inhibitors

Kovada, V.; Pulle, T.; Suna, E. Chiral Epoxy-Imine Building Block for Diversity-Oriented Synthesis of Peptidomimetic Aspartic Protease Inhibitors. J. Org. Chem. 2025, 90 (30), 10771–10785. DOI: 10.1021/acs.joc.5c01092

58. GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity

Motso, A.; Pelcman, B.; Kalinovich, A.; Kahlous, N. A.; Bokhari, M. H.; Dehvari, N.; Halleskog, C.; Waara, E.; de Jong, J.; Cheesman, E.; Kallenberg, C.; Yakala, G. K.; Murad, P.; Wetterdal, E.; Andersson, P.; van Beek, S.; Sandström, A.; Alleluia, D. N.; Talamonti, E.; Youhanna, S.; Sabatier, P.; Koenig, C.; Willems, S.; Kemas, A. M.; Hutchinson, D. S.; Ham, S.; Grätz, L.; Voss, J.; Marchan-Alvarez, J. G.; Priede, M.; Jaunsleine, K.; Spura, J.; Kovada, V.; Supe, L.; Stoddart, L. A.; Holliday, N. D.; Newton, P. T.; Pillon, N. J.; Schulte, G.; Summers, R. J.; Mutule, I.; Suna, E.; Olsen, J. V.; Molenaar, P.; Carlsson, J.; Lauschke, V. M.; Wright, S. C.; Bengtsson, T. GRK-Biased Adrenergic Agonists for the Treatment of Type 2 Diabetes and Obesity. Cell 2025, 188 (19), 5142–5156. DOI: 10.1016/j.cell.2025.05.042

57. Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters

Koleda O., Sadauskis J., Antonenko D., Treijs E. J., Steberis R. D., Suna E. Beilstein J. Org. Chem. 2025, 21, 630–638.
DOI: 10.3762/bjoc.21.50

56. S-Alkylation of sulfinamides with Zn-carbenoids: expanding stereoselective sulfoximine synthesis beyond NH derivatives

Jersovs G., Melgalvis D., Kinens A., Donets P. A., Suna E. Org. Chem. Front., 2025, 12, 14-23.
DOI: 10.1039/D4QO01931H

55. Tailoring Emission Lifetime for Dopant-Induced Phosphorescence

Mazarevics, A.; Kinens, A.; Leduskrasts, K.; Suna, E. ACS Materials Lett., 2024, 6, 4590-4595.
DOI: 10.1021/acsmaterialslett.4c01412

54. Impurity-Induced Phosphorescence in Purely Organic Materials

Mazarevics A., Leduskrasts K., Suna E. ACS Materials Lett. 2024, 6, 2703–2713.
DOI: 10.1021/acsmaterialslett.4c00447.

53. Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide

Kalnins T., Vitkovska V., Kazak M., Zelencova-Gopejenko D., Ozola M., Narvaiss N., Makrecka-Kuka M., Domračeva I., Kinens A., Gukalova B., Konrad N., Aav R., Bonato F., Lucena-Agell D., Díaz J. F., Liepinsh E., Suna E. J. Med. Chem., 2024, 67 (11), 9227–9259.
DOI: 10.1021/acs.jmedchem.4c00388.

52. The Novel Adrenergic Agonist ATR-127 Targets Skeletal Muscle and Brown Adipose Tissue to Tackle Diabesity and Steatohepatitis

Talamonti E., Davegardh J., Kalinovich A., van Beek S. M. M., Dehvari N., Halleskog C., Bokhari H. M., Hutchinson D. S., Ham S., Humphrys L. J., Dijon N. C., Motso A., Sandstrom A., Zacharewicz E., Mutule I., Suna E., Spura J., Ditrychova K., Stoddart L. A., Holliday N. D., Bengtsson T. Molecular Metabolism, 2024, 101931.
DOI: 10.1016/j.molmet.2024.101931.

51. Chiral 4-MeO-Pyridine (MOPY) Catalyst for Enantioselective Cyclopropanation: Attenuation of Lewis Basicity Leads to Improved Catalytic Efficiency

Kluga R., Kinens A., Suna E. Chem. Eur. J. 2024, e202301136
DOI: 10.1002/chem.202301136.

50. Development of novel β2-adrenergic receptor agonists for the stimulation of glucose uptake – The importance of chirality and ring size of cyclic amines

Jaunsleine, K.; Supe, L.; Spura, J.; van Beek, S.; Sandström, A.; Olsen, J.; Halleskog, C.; Bengtsson, T.; Mutule, I.; Pelcman, B. Bioorganic & Medicinal Chemistry Letters 2024, 97, 129562. DOI: 10.1016/j.bmcl.2023.129562.

49. Synthesis and Evaluation of Novel 5-O-(4-C-Aminoalkyl-β-D-ribofuranosyl) Apramycin Derivatives for the Inhibition of Gram-Negative Pathogens Carrying the Aminoglycoside Phosphotransferase(3′)-Ia Resistance Determinant

Lubriks, D.; Haldimann, K.; Kiliç, F.; Hartmann, M.; Böttger, E. C.; Hobbie, S. N.; Suna, E.; Crich, D. Helv. Chim. Acta 2023, e202300138
DOI: 10.1002/hlca.202300138.

48. Pyrazolidinone-based peptidomimetic SARS-CoV-2 Mpro inhibitors

Jelisejevs D., Bula A. L., Kinena L. Bioorg. Med. Chem. Lett. 2023, 96, 129530
DOI: 10.1016/j.bmcl.2023.129530.

47. Electrochemical Synthesis of Unnatural Amino Acids via Anodic Decarboxylation of N-Acetylamino Malonic Acid Derivatives

Koleda O., Prane K., Suna E. Org. Lett. 2023, 25 (44), 7958–7962.
DOI: https://doi.org/10.1021/acs.orglett.3c02687.

46. Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity

Kovada, V.; Withers-Martinez, C.; Bobrovs, R.; Ce̅rule, H.; Liepins, E.; Grinberga, S.; Hackett, F.; Collins, C. R.; Kreicberga, A.; Jiménez-Díaz, M. B.; Angulo-Barturen, I.; Rasina, D.; Suna, E.; Jaudzems, K.; Blackman, M. J.; Jirgensons, A. J. Med. Chem. 2023, 66, 15, 10658–10680.
DOI: https://doi.org/10.1021/acs.jmedchem.3c00812.

45. The emission efficiency of cationic solid state luminophores is directly proportional to the intermolecular charge transfer intensity

Leduskrasts, K.; Kinens, A.; Suna, E.; Chem. Commun. 2023, 59, 6905 – 6908. Download publication. DOI: 10.1039/d3cc01674a

44. Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183

Baran, A.; Kuzmins, J.; Kuznecovs, J.; Farley, A., J., M.; Panduwawala, T.; Parkova, A.; Donets, P., A.; Brem, J.; Suna, E.; Schofield, C., J.; Shubin, K. Org. Process Res. Dev. 2023, 27, 692–706. DOI:10.1021/acs.oprd.3c00002

43. Electrochemical Synthesis of Dimeric λ3-Bromane: Platform for Hypervalent Bromine(III) Compounds

Sokolovs, I.; Suna, E.; Org. Lett. 2023, 25, 2047–2052. DOI: 10.1021/acs.orglett.3c00405

42. Simple and scalable electrosynthesis of 1H-1-hydroxy-quinazolin-4-ones

Koleda, O.; Prenzel, T,; Winter, J.; Hirohata, T.; Gálvez-Vázquez, J.; Schollmeyer, D.; Inagi, S.; Suna, E.; Waldvogel, S. R.; Chem. Sci. 2023, 14, 2669-2675. DOI: 10.1039/D3SC00266G

41. Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)

Lubriks, D.; Haldimann, K.; Hobbie, S. N.; Vasella A.; Suna E.; Crich D.; Antibiotics 2023, 12, 25–39. DOI: 10.3390/antibiotics12010025

40. Electrochemistry and Reactivity of Chelation-stabilized Hypervalent Bromine(III) Compounds

Mohebbati, N.; Sokolovs, i.; Woite, P.; Lõkov, M.; Parman, E.; Ugandi, M.; Leito, I.; Roemelt, M.; Suna, E.; Francke, R.; Chem-Eur. J. 2022, 28, e202200974.

DOI: 10.1002/chem.202200974